Human APOBEC3 Variations and Viral Infection.
APOBEC Deaminases
/ genetics
Cytidine Deaminase
/ genetics
Cytosine Deaminase
/ genetics
HIV-1
/ physiology
Hepatitis B virus
/ physiology
Host-Pathogen Interactions
/ genetics
Humans
Immunity, Innate
/ immunology
Polymorphism, Genetic
/ genetics
Protein Isoforms
/ genetics
Virus Diseases
/ genetics
Virus Replication
/ genetics
APOBEC3
HBV
HIV
Polymorphism
Splice variants
Journal
Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722
Informations de publication
Date de publication:
14 07 2021
14 07 2021
Historique:
received:
11
05
2021
revised:
07
07
2021
accepted:
08
07
2021
entrez:
10
8
2021
pubmed:
11
8
2021
medline:
18
9
2021
Statut:
epublish
Résumé
Human APOBEC3 (apolipoprotein B mRNA-editing catalytic polypeptide-like 3) enzymes are capable of inhibiting a wide range of endogenous and exogenous viruses using deaminase and deaminase-independent mechanisms. These enzymes are essential components of our innate immune system, as evidenced by (a) their strong positive selection and expansion in primates, (b) the evolution of viral counter-defense mechanisms, such as proteasomal degradation mediated by HIV Vif, and (c) hypermutation and inactivation of a large number of integrated HIV-1 proviruses. Numerous APOBEC3 single nucleotide polymorphisms, haplotypes, and splice variants have been identified in humans. Several of these variants have been reported to be associated with differential antiviral immunity. This review focuses on the current knowledge in the field about these natural variations and their roles in infectious diseases.
Identifiants
pubmed: 34372572
pii: v13071366
doi: 10.3390/v13071366
pmc: PMC8310219
pii:
doi:
Substances chimiques
Protein Isoforms
0
Cytosine Deaminase
EC 3.5.4.1
APOBEC Deaminases
EC 3.5.4.5
APOBEC3 proteins, human
EC 3.5.4.5
Cytidine Deaminase
EC 3.5.4.5
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIAID NIH HHS
ID : R21 AI138793
Pays : United States
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