Gut micobiota alteration by Lactobacillus rhamnosus reduces pro-inflammatory cytokines and glucose level in the adult model of Zebrafish.
Cytokine
Lactobacillus rhamnosus
Probiotic
Type 2 diabetes mellitus (T2DM)
Zebrafish
Journal
BMC research notes
ISSN: 1756-0500
Titre abrégé: BMC Res Notes
Pays: England
ID NLM: 101462768
Informations de publication
Date de publication:
09 Aug 2021
09 Aug 2021
Historique:
received:
17
04
2021
accepted:
19
07
2021
entrez:
10
8
2021
pubmed:
11
8
2021
medline:
12
8
2021
Statut:
epublish
Résumé
Type 2 diabetes mellitus (T2DM) is still a challenge for physicians to manage patient's circumstances. It is assumed that alterations in the normal flora may be involved in the pathogenesis of T2DM through inducing chronic inflammation. To investigate the effect of Lactobacillus rhamnosus as a common probiotic on T2DM, we induced an experimental model of T2DM in adult male Zebrafish by gradient hyper-glucose accumulation methodology. In this trial 3-month old male adult Zebrafish were divided in to four groups including two control groups and T2DM induced groups with or without probiotic treatment. After 5 days of acclimation, T2DM was induced by a gradient hyper-glucose accumulation methodology. Diabetic fishes had statistically abnormal blood glucose and pro-inflammatory cytokine levels compared to control group (p = 0.0001). These results suggest that probiotic intervention decreased the blood glucose level in the T2DM-P group by decreasing pro-inflammatory cytokines responsible for signaling in T2DM therapeutic modalities.
Identifiants
pubmed: 34372916
doi: 10.1186/s13104-021-05706-5
pii: 10.1186/s13104-021-05706-5
pmc: PMC8351095
doi:
Substances chimiques
Cytokines
0
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
302Subventions
Organisme : Tehran University of Medical Sciences
ID : 2129
Informations de copyright
© 2021. The Author(s).
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