Molecular Pathology of Urothelial Carcinoma.

Carcinoma, Transitional Cell / genetics Genomics Humans Pathology, Molecular Urinary Bladder Neoplasms / genetics
Molecular classification Molecular pathology Urothelial carcinoma

Journal

Surgical pathology clinics
ISSN: 1875-9157
Titre abrégé: Surg Pathol Clin
Pays: United States
ID NLM: 101491209

Informations de publication

Date de publication:
Sep 2021
Historique:
entrez: 10 8 2021
pubmed: 11 8 2021
medline: 29 10 2021
Statut: ppublish

Résumé

Urothelial carcinoma is characterized by the presence of a wide spectrum of histopathologic features and molecular alterations that contribute to its morphologic and genomic heterogeneity. It typically harbors high rates of somatic mutations with considerable genomic and transcriptional complexity and heterogeneity that is reflective of its varied histomorphologic and clinical features. This review provides an update on the recent advances in the molecular characterization and novel molecular taxonomy of urothelial carcinoma and variant histologies.

Identifiants

DOI: 10.1016/j.path.2021.05.005 PMID: 34373092 PMC: PMC9175507
pubmed: 34373092
pii: S1875-9181(21)00039-8
doi: 10.1016/j.path.2021.05.005
pmc: PMC9175507
mid: NIHMS1811935
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

403-414

Subventions

Organisme : NCI NIH HHS
ID : P01 CA221757
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA221745
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA233899
Pays : United States

Informations de copyright

Copyright © 2021 Elsevier Inc. All rights reserved.

Références

Mod Pathol. 2009 Jun;22 Suppl 2:S96-S118
pubmed: 19494856
Mol Oncol. 2016 Nov;10(9):1450-1460
pubmed: 27582092
J Pathol. 2017 May;242(1):113-125
pubmed: 28195647
Hum Pathol. 2018 Jul;77:63-69
pubmed: 29601842
Nat Genet. 2016 Apr;48(4):356-8
pubmed: 26901067
JAMA Oncol. 2020 Jan 01;6(1):84-91
pubmed: 31725847
Eur Urol. 2016 Oct;70(4):611-620
pubmed: 26988609
Clin Cancer Res. 2014 Jan 1;20(1):68-75
pubmed: 24192927
Cancer Discov. 2018 Jul;8(7):812-821
pubmed: 29848605
Virchows Arch. 2020 Sep;477(3):445-454
pubmed: 32198650
Urology. 2014 May;83(5):1112-6
pubmed: 24582117
J Pathol. 2007 Mar;211(4):420-30
pubmed: 17236170
Int J Cancer. 2011 Jul 15;129(2):346-54
pubmed: 20878954
Arch Pathol Lab Med. 2016 Jun;140(6):543-51
pubmed: 27031776
Nature. 2013 Jul 11;499(7457):214-218
pubmed: 23770567
Bladder Cancer. 2016 Jan 7;2(1):37-47
pubmed: 27376123
Mod Pathol. 2011 Aug;24(8):1111-9
pubmed: 21516078
Nat Rev Clin Oncol. 2018 Aug;15(8):495-509
pubmed: 29720713
Cell. 2018 Apr 5;173(2):515-528.e17
pubmed: 29625057
iScience. 2020 Jun 26;23(6):101201
pubmed: 32521509
Arch Pathol Lab Med. 2007 Nov;131(11):1725-7
pubmed: 17979494
Int J Cancer. 2020 May 1;146(9):2636-2647
pubmed: 31609466
Lancet. 2016 May 7;387(10031):1909-20
pubmed: 26952546
Science. 2020 Oct 2;370(6512):75-82
pubmed: 33004514
Eur Urol. 2018 Dec;74(6):741-753
pubmed: 30033047
Science. 2020 Oct 2;370(6512):82-89
pubmed: 33004515
Mod Pathol. 2018 Dec;31(12):1869-1881
pubmed: 29967424
Nat Rev Urol. 2020 May;17(5):259-270
pubmed: 32235944
Elife. 2018 Mar 20;7:
pubmed: 29557778
Hum Pathol. 2010 Feb;41(2):163-71
pubmed: 19800100
J Urol. 2013 Nov;190(5):1692-6
pubmed: 23707452
N Engl J Med. 2019 Jul 25;381(4):338-348
pubmed: 31340094
Eur Urol. 2020 Apr;77(4):420-433
pubmed: 31563503
Clin Cancer Res. 2012 Jun 15;18(12):3377-86
pubmed: 22553347
Mod Pathol. 2019 Oct;32(10):1544-1550
pubmed: 31028363
Cancer Cell. 2014 Feb 10;25(2):152-65
pubmed: 24525232
Mod Pathol. 2003 Dec;16(12):1289-98
pubmed: 14681330
Oncogene. 2018 May;37(22):3039-3044
pubmed: 29535424
J Clin Oncol. 2013 Sep 1;31(25):3133-40
pubmed: 23897969
Am J Pathol. 2013 Sep;183(3):681-91
pubmed: 23827819
J Clin Oncol. 2018 Jul 1;36(19):1949-1956
pubmed: 29742009
J Clin Oncol. 2018 Jun 10;36(17):1710-1713
pubmed: 29683789
Urol Oncol. 2019 Nov;37(11):826-836
pubmed: 31585777
Cancers (Basel). 2020 Mar 24;12(3):
pubmed: 32213857
Cell Rep. 2019 May 7;27(6):1781-1793.e4
pubmed: 31067463
Clin Cancer Res. 2017 Jul 15;23(14):3610-3618
pubmed: 28137924
J Pathol. 2019 Jun;248(2):230-242
pubmed: 30719704
Virchows Arch. 2015 Jun;466(6):703-10
pubmed: 25809292
Nat Genet. 2016 Jun;48(6):600-606
pubmed: 27111033
Adv Anat Pathol. 2020 Jan;27(1):36-43
pubmed: 31743118
Nature. 2014 Mar 20;507(7492):315-22
pubmed: 24476821
Cancer Discov. 2012 May;2(5):401-4
pubmed: 22588877
J Urol. 1998 May;159(5):1497-503
pubmed: 9554341
Eur Urol. 2017 Oct;72(4):544-554
pubmed: 28390739
Ann Diagn Pathol. 2015 Oct;19(5):301-5
pubmed: 26239299
Cell. 2017 Oct 19;171(3):540-556.e25
pubmed: 28988769
Eur Urol Focus. 2019 Mar;5(2):201-204
pubmed: 28802642
Cancer Res. 2013 Dec 15;73(24):7162-7
pubmed: 24121487
Clin Cancer Res. 2018 Apr 15;24(8):1965-1973
pubmed: 29180607
Cancer. 2016 Dec 1;122(23):3715-3723
pubmed: 27479538
Sci Rep. 2018 Feb 27;8(1):3737
pubmed: 29487377
Cancer Discov. 2014 Oct;4(10):1140-53
pubmed: 25096233
Nature. 2018 Feb 8;554(7691):189-194
pubmed: 29420467
Eur Urol. 2019 Jan;75(1):18-22
pubmed: 30266310
Mod Pathol. 2014 May;27(5):758-64
pubmed: 24186136
Hum Pathol. 2019 Mar;85:1-9
pubmed: 30447301
Nat Rev Urol. 2017 Feb 07;14(4):215-229
pubmed: 28169993
J Clin Oncol. 2018 Jun 10;36(17):1685-1694
pubmed: 29489427
Am J Surg Pathol. 2015 Jan;39(1):127-31
pubmed: 25118812
Urology. 2007 Jul;70(1):69-74
pubmed: 17656211
Sci Signal. 2013 Apr 02;6(269):pl1
pubmed: 23550210
Histopathology. 2018 Apr;72(5):795-803
pubmed: 29193225
Am J Surg Pathol. 2003 Sep;27(9):1243-52
pubmed: 12960809
Urol Oncol. 2013 Nov;31(8):1650-5
pubmed: 22608543
Proc Natl Acad Sci U S A. 2014 Feb 25;111(8):3110-5
pubmed: 24520177
Histopathology. 2018 Jan;72(2):354-356
pubmed: 28741734
Am J Surg Pathol. 2009 Mar;33(3):417-24
pubmed: 19011563
Am J Surg Pathol. 2011 Sep;35(9):1337-42
pubmed: 21836490
Histopathology. 2017 Nov;71(5):703-710
pubmed: 28805264
Histopathology. 2019 Dec;75(6):865-875
pubmed: 31348552
J Pathol. 2019 Jul;248(3):260-265
pubmed: 30838648
Nat Genet. 2011 Aug 07;43(9):875-8
pubmed: 21822268
Eur Urol. 2011 Aug;60(2):350-7
pubmed: 21640482
Mod Pathol. 2020 Jun;33(6):1165-1171
pubmed: 31932679
Am J Clin Pathol. 2021 Mar 15;155(4):588-596
pubmed: 33118597
J Urol. 2013 May;189(5):1656-61
pubmed: 23159581
Eur Urol. 2017 Dec;72(6):952-959
pubmed: 28583311

Auteurs

Hikmat Al-Ahmadie (H)

Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NW 10065, USA. Electronic address: alahmadh@mskcc.org.

George J Netto (GJ)

Department of Pathology, University of Alabama at Birmingham, University of Alabama at Birmingham School of Medicine, WP Building, Suite P230, 619 19th Street South, Birmingham, AL 35249-7331, USA. Electronic address: gnetto@uab.edu.

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Classifications MeSH

questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs épithéliales épidermoïdes et glandulaires › Carcinomes › Carcinome transitionnel › Molecular Pathology of Urothelial Carcinoma.
questionsmedicales.fr › Disciplines des sciences naturelles › Disciplines des sciences biologiques › Biologie › Génétique › Génomique › Molecular Pathology of Urothelial Carcinoma.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Molecular Pathology of Urothelial Carcinoma.
questionsmedicales.fr › Professions de santé › Médecine › Anatomopathologie › Anatomopathologie moléculaire › Molecular Pathology of Urothelial Carcinoma.
questionsmedicales.fr › Maladies urogénitales › Maladies urologiques › Tumeurs urologiques › Tumeurs de la vessie urinaire › Molecular Pathology of Urothelial Carcinoma.