Time course of risk factors associated with mortality of 1260 critically ill patients with COVID-19 admitted to 24 Italian intensive care units.
COVID-19
Intensive care unit
Longitudinal models
Mortality
Predictors
Time course
Journal
Intensive care medicine
ISSN: 1432-1238
Titre abrégé: Intensive Care Med
Pays: United States
ID NLM: 7704851
Informations de publication
Date de publication:
09 2021
09 2021
Historique:
received:
01
04
2021
accepted:
22
07
2021
pubmed:
11
8
2021
medline:
10
9
2021
entrez:
10
8
2021
Statut:
ppublish
Résumé
To evaluate the daily values and trends over time of relevant clinical, ventilatory and laboratory parameters during the intensive care unit (ICU) stay and their association with outcome in critically ill patients with coronavirus disease 19 (COVID-19). In this retrospective-prospective multicentric study, we enrolled COVID-19 patients admitted to Italian ICUs from February 22 to May 31, 2020. Clinical data were daily recorded. The time course of 18 clinical parameters was evaluated by a polynomial maximum likelihood multilevel linear regression model, while a full joint modeling was fit to study the association with ICU outcome. 1260 consecutive critically ill patients with COVID-19 admitted in 24 ICUs were enrolled. 78% were male with a median age of 63 [55-69] years. At ICU admission, the median ratio of arterial oxygen partial pressure to fractional inspired oxygen (PaO Daily values or trends over time of parameters associated with acute organ dysfunction, acid-base derangement, coagulation impairment, or systemic inflammation were associated with patient survival.
Identifiants
pubmed: 34373952
doi: 10.1007/s00134-021-06495-y
pii: 10.1007/s00134-021-06495-y
pmc: PMC8351771
doi:
Banques de données
ClinicalTrials.gov
['NCT04388670']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
995-1008Subventions
Organisme : Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
ID : Ricerca Corrente 2020
Organisme : Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
ID : PB-0154 PROGETTO COVID-2020-12371675
Investigateurs
Massimo Antonelli
(M)
Michele Aspesi
(M)
Federica Baccanelli
(F)
Flavio Bassi
(F)
Giacomo Bellani
(G)
Angela Berselli
(A)
Andrzej Bet
(A)
Emanuela Biagioni
(E)
Alberto Biondo
(A)
Chiara Bonenti
(C)
Nicola Bottino
(N)
Tiziana Bove
(T)
Luca Brazzi
(L)
Ilaria Buquicchio
(I)
Stefano Busani
(S)
Luca Cabrini
(L)
Angelo Calini
(A)
Plinio Calligaro
(P)
Leonarda Pia Cantatore
(LP)
Simone Carelli
(S)
Eleonora Carlesso
(E)
Andrea Carsetti
(A)
Gian Paolo Castelli
(GP)
Sara Cavallini
(S)
Maurizio Cecconi
(M)
Giacomo Cimicchi
(G)
Giuseppe Citerio
(G)
Irene Coloretti
(I)
Andrea Coppadoro
(A)
Daniele Corti
(D)
Lorenzo Dall'Ara
(L)
Francesca Dalla Corte
(F)
Edoardo De Robertis
(E)
Valentina Di Gravio
(V)
Mattia Erba
(M)
Giulia Evasi
(G)
Alberto Facchini
(A)
Vito Fanelli
(V)
Giancarlo Feliciotti
(G)
Chiara Ferraris Fusarini
(CF)
Gioconda Ferraro
(G)
Gaetano Florio
(G)
Giuseppe Foti
(G)
Roberto Fumagalli
(R)
Giuseppe Gagliardi
(G)
Roberta Garberi
(R)
Hedwige Gay
(H)
Laura Giacchè
(L)
Massimo Girardis
(M)
Riccardo Giudici
(R)
Giacomo Grasselli
(G)
Domenico Grieco
(D)
Lorenzo Guiotto
(L)
Amedeo Guzzardella
(A)
Thomas Langer
(T)
Federico Longhini
(F)
Andrea Manzan
(A)
Davide Maraggia
(D)
Angelo Milani
(A)
Lucia Mirabella
(L)
Anna Mischi
(A)
Carlo Montalto
(C)
Sara Mormina
(S)
Valentina Noseda
(V)
Chiara Paleari
(C)
Daniela Pasero
(D)
Matteo Pedeferri
(M)
Antonio Pesenti
(A)
Angelo Pezzi
(A)
Giacinto Pizzilli
(G)
Matteo Pozzi
(M)
Paolo Properzi
(P)
Alessandro Protti
(A)
Marco V Ranieri
(MV)
Michela Rauseo
(M)
Roberto Rona
(R)
Vincenzo Russotto
(V)
Luca Saccarelli
(L)
Luigia Scudeller
(L)
Giuseppe Servillo
(G)
Paolo Severgnini
(P)
Savino Spadaro
(S)
Sofia Spano
(S)
Nino Stocchetti
(N)
Paola Tagliabue
(P)
Tommaso Tonetti
(T)
Livio Tullo
(L)
Luigi Vetrugno
(L)
Martina Viganò
(M)
Luigi Vivona
(L)
Carlo Alberto Volta
(CA)
Vanessa Zambelli
(V)
Alberto Zanella
(A)
Andrea Zanoni
(A)
Informations de copyright
© 2021. The Author(s).
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