PIWI proteins and piRNAs in cervical cancer: a propitious dart in cancer stem cell-targeted therapy.
CSC-targeted therapy
Cancer stem cells
Cervical cancer
Liquid biopsy
PIWI
piRNA
Journal
Human cell
ISSN: 1749-0774
Titre abrégé: Hum Cell
Pays: Japan
ID NLM: 8912329
Informations de publication
Date de publication:
Nov 2021
Nov 2021
Historique:
received:
07
06
2021
accepted:
02
08
2021
pubmed:
11
8
2021
medline:
27
1
2022
entrez:
10
8
2021
Statut:
ppublish
Résumé
Any form of cancer is a result of uncontrolled cell growth caused by mutations and/or epigenetic alterations, implying that a balance of chromatin remodeling activities and epigenetic regulators is crucial to prevent the transformation of a normal cell to a cancer cell. Many of the chromatin remodelers do not recognize any specific sites on their targets and require guiding molecules to reach the respective targets. PIWI proteins and their interacting small non-coding RNAs (piRNAs) have proved to act as a guiding signal for such molecules. While epigenetic alterations lead to tumorigenesis, the stemness of cancer cells contributes to recurrence and metastasis of cancer. Various studies have propounded that the PIWI-piRNA complex also promotes stemness of cancer cells, providing new doors for target-mediated anti-cancer therapies. Despite the progress in diagnosis and development of vaccines, cervical cancer remains to be the second most prevalent cancer among women, due to the lack of cost-effective and accessible diagnostic and prevention methods. With the emergence of liquid biopsy, there is a significant demand for the ideal biomarker in the diagnosis of cancer. PIWI and piRNAs have been recommended to serve as prognostic and diagnostic markers, to differentiate early and later stages of cancer, including cervical cancer. This review discusses how PIWIs and piRNAs are involved in disease progression as well as their potential role in diagnostics and therapeutics in cervical cancer.
Identifiants
pubmed: 34374035
doi: 10.1007/s13577-021-00590-4
pii: 10.1007/s13577-021-00590-4
doi:
Substances chimiques
Argonaute Proteins
0
Biomarkers, Tumor
0
PIWIL1 protein, human
0
RNA, Small Untranslated
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1629-1641Informations de copyright
© 2021. Japan Human Cell Society.
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