Intestinal immunity: to be, or not to be, induced? That is the question.
IgA
M cell
commensal microbiota
fasting
intestinal immune system
Journal
International immunology
ISSN: 1460-2377
Titre abrégé: Int Immunol
Pays: England
ID NLM: 8916182
Informations de publication
Date de publication:
25 11 2021
25 11 2021
Historique:
received:
22
07
2021
accepted:
09
08
2021
pubmed:
11
8
2021
medline:
23
3
2022
entrez:
10
8
2021
Statut:
ppublish
Résumé
The intestinal immune system maintains intestinal homeostasis in collaboration with diverse immune cell subsets residing at the epithelial layer, lamina propria and gut-associated lymphoid tissue (GALT). Bacterial components and their metabolites are essential for the establishment of the gut immune system. In addition, nutritional signals contribute to maintaining the mucosal immune response. Specialized epithelial microfold (M) cells in GALT facilitate immune surveillance on the mucosal surface by actively taking up external antigens to transport them into the lymphoid follicles. Because hyperplasia of M cells causes an excessive immune response in GALT, there is a self-regulatory mechanism to control the development of M cells appropriately. In this review, we will discuss the molecular mechanisms of mucosal immune regulation and their biological importance.
Identifiants
pubmed: 34375433
pii: 6347559
doi: 10.1093/intimm/dxab051
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
755-759Informations de copyright
© The Japanese Society for Immunology. 2021. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.