The intrinsically disorderly story of Ki-67.
Ki-67
cell division
mitosis
mitotic chromosome periphery
nucleolus
phase separation
Journal
Open biology
ISSN: 2046-2441
Titre abrégé: Open Biol
Pays: England
ID NLM: 101580419
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
entrez:
10
8
2021
pubmed:
11
8
2021
medline:
8
3
2022
Statut:
ppublish
Résumé
Ki-67 is one of the most famous marker proteins used by histologists to identify proliferating cells. Indeed, over 30 000 articles referring to Ki-67 are listed on PubMed. Here, we review some of the current literature regarding the protein. Despite its clinical importance, our knowledge of the molecular biology and biochemistry of Ki-67 is far from complete, and its exact molecular function(s) remain enigmatic. Furthermore, reports describing Ki-67 function are often contradictory, and it has only recently become clear that this proliferation marker is itself dispensable for cell proliferation. We discuss the unusual organization of the protein and its mRNA and how they relate to various models for its function. In particular, we focus on ways in which the intrinsically disordered structure of Ki-67 might aid in the assembly of the still-mysterious mitotic chromosome periphery compartment by controlling liquid-liquid phase separation of nucleolar proteins and RNAs.
Identifiants
pubmed: 34375547
doi: 10.1098/rsob.210120
pmc: PMC8354752
doi:
Substances chimiques
Intrinsically Disordered Proteins
0
Ki-67 Antigen
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
210120Subventions
Organisme : Wellcome Trust
ID : 107022
Pays : United Kingdom
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