Hypoxia inducible factor 1-α is minimally involved in determining the time domains of the hypoxic ventilatory response in adult zebrafish (Danio rerio).
Control of breathing
Gene knockout
Hypoxia inducible factor-1α
Hypoxic ventilatory decline
Hypoxic ventilatory response (HVR)
Zebrafish
Journal
Respiratory physiology & neurobiology
ISSN: 1878-1519
Titre abrégé: Respir Physiol Neurobiol
Pays: Netherlands
ID NLM: 101140022
Informations de publication
Date de publication:
12 2021
12 2021
Historique:
received:
10
02
2021
revised:
20
04
2021
accepted:
05
08
2021
pubmed:
11
8
2021
medline:
2
2
2022
entrez:
10
8
2021
Statut:
ppublish
Résumé
In the current study, adult zebrafish (Danio rerio) were exposed to 72 h hypoxia (90 mmHg) to assess the time domains of the hypoxia ventilatory response (HVR) and the consequence on a subsequent more severe (40 mmHg) bout of acute hypoxia. Experiments were performed on wild-type fish and mutants in which one or both paralogs of hypoxia inducible factor-1α (hif-1α) were knocked out. Although there were subtle differences among the wild-type and knockout fish, resting f
Identifiants
pubmed: 34375733
pii: S1569-9048(21)00159-2
doi: 10.1016/j.resp.2021.103774
pii:
doi:
Substances chimiques
Hypoxia-Inducible Factor 1, alpha Subunit
0
hif1aa protein, zebrafish
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
103774Informations de copyright
Copyright © 2021 Elsevier B.V. All rights reserved.