Mevalonate kinase of Leishmania donovani protects parasite against oxidative stress by modulating ergosterol biosynthesis.

Animals Ergosterol / biosynthesis Hydrogen Peroxide / toxicity Leishmania donovani / enzymology Oxidative Stress / physiology Phosphotransferases (Alcohol Group Acceptor) / metabolism
Ergosterol Leishmania donovani Leishmania survival Mevalonate kinase Oxidative stress

Journal

Microbiological research
ISSN: 1618-0623
Titre abrégé: Microbiol Res
Pays: Germany
ID NLM: 9437794

Informations de publication

Date de publication:
Oct 2021
Historique:
received: 26 02 2021
revised: 24 07 2021
accepted: 01 08 2021
pubmed: 11 8 2021
medline: 4 1 2022
entrez: 10 8 2021
Statut: ppublish

Résumé

Leishmaniasis comprises of a wide variety of diseases, caused by protozoan parasite belonging to the genus Leishmania. Leishmania parasites undergo different types of stress during their lifetime and have developed strategies to overcome this damage. Identifying the mechanistic approach used by the parasite in dealing with the stress is of immense importance for unfolding the survival strategy adopted by the parasite. Mevalonate kinase (MVK) is an important regulatory factor in the mevalonate pathway in both bacteria and eukaryotes. In this study, we explored the role of Leishmania donovani mevalonate kinase (LdMVK) in parasite survival under stress condition. Hydrogen peroxide (H

Identifiants

DOI: 10.1016/j.micres.2021.126837 PMID: 34375804
pubmed: 34375804
pii: S0944-5013(21)00143-9
doi: 10.1016/j.micres.2021.126837
pii:
doi:

Substances chimiques

Hydrogen Peroxide BBX060AN9V
Phosphotransferases (Alcohol Group Acceptor) EC 2.7.1.-
mevalonate kinase EC 2.7.1.36
Ergosterol Z30RAY509F

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

126837

Informations de copyright

Copyright © 2021. Published by Elsevier GmbH.

Auteurs

Md Taj Shafi (MT)

Department of Molecular Biology, ICMR- Rajendra Memorial Research Institute of Medical Sciences, Agamkuan, Patna, Bihar, 800 007, India.

Tanvir Bamra (T)

Department of Molecular Biology, ICMR- Rajendra Memorial Research Institute of Medical Sciences, Agamkuan, Patna, Bihar, 800 007, India.

Sushmita Das (S)

Department of Microbiology, All India Institute of Medical Sciences, Phulwarisharif, Patna, Bihar, 801 507, India.

Ashish Kumar (A)

Department of Biochemistry, ICMR- Rajendra Memorial Research Institute of Medical Sciences, Agamkuan, Patna, Bihar, 800 007, India.

Kumar Abhishek (K)

Department of Molecular Biology, ICMR- Rajendra Memorial Research Institute of Medical Sciences, Agamkuan, Patna, Bihar, 800 007, India.

Manjay Kumar (M)

Department of Molecular Biology, ICMR- Rajendra Memorial Research Institute of Medical Sciences, Agamkuan, Patna, Bihar, 800 007, India.

Vinod Kumar (V)

Department of Molecular Biology, ICMR- Rajendra Memorial Research Institute of Medical Sciences, Agamkuan, Patna, Bihar, 800 007, India.

Ajay Kumar (A)

Department of Molecular Biology, ICMR- Rajendra Memorial Research Institute of Medical Sciences, Agamkuan, Patna, Bihar, 800 007, India.

Rimi Mukherjee (R)

Department of Molecular Biology, ICMR- Rajendra Memorial Research Institute of Medical Sciences, Agamkuan, Patna, Bihar, 800 007, India.

Abhik Sen (A)

Department of Molecular Biology, ICMR- Rajendra Memorial Research Institute of Medical Sciences, Agamkuan, Patna, Bihar, 800 007, India.

Pradeep Das (P)

Department of Molecular Biology, ICMR- Rajendra Memorial Research Institute of Medical Sciences, Agamkuan, Patna, Bihar, 800 007, India; Department of Microbiology, Indira Gandhi Institute of Medical Sciences, Sheikhpura, Patna, Bihar, 800 014, India. Electronic address: drpradeep.das@gmail.com.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Mevalonate kinase of Leishmania donovani...
questionsmedicales.fr › Composés polycycliques › Composés à cycles fusionnés › Stéroïdes › Cholestanes › Cholestènes › Ergostérol › Mevalonate kinase of Leishmania donovani...
questionsmedicales.fr › Composés chimiques organiques › Radicaux libres › Peroxydes › Peroxyde d'hydrogène › Mevalonate kinase of Leishmania donovani...
questionsmedicales.fr › Eucaryotes › Euglénozoaires › Kinetoplastida › Trypanosomatina › Leishmania › Leishmania donovani › Mevalonate kinase of Leishmania donovani...
questionsmedicales.fr › Phénomènes physiologiques › Stress physiologique › Stress oxydatif › Mevalonate kinase of Leishmania donovani...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Phosphotransferases › Phosphotransferases (Alcohol Group Acceptor) › Mevalonate kinase of Leishmania donovani...