Structured to conquer: transport across the Plasmodium parasitophorous vacuole.
Journal
Current opinion in microbiology
ISSN: 1879-0364
Titre abrégé: Curr Opin Microbiol
Pays: England
ID NLM: 9815056
Informations de publication
Date de publication:
10 2021
10 2021
Historique:
received:
31
03
2021
revised:
13
07
2021
accepted:
19
07
2021
pubmed:
11
8
2021
medline:
4
10
2022
entrez:
10
8
2021
Statut:
ppublish
Résumé
During the vertebrate stage of the Plasmodium life cycle, obligate intracellular malaria parasites establish a vacuolar niche for replication, first within host hepatocytes at the pre-patent liver-stage and subsequently in erythrocytes during the pathogenic blood-stage. Survival in this protective microenvironment requires diverse transport mechanisms that enable the parasite to transcend the vacuolar barrier. Effector proteins exported out of the vacuole modify the erythrocyte membrane, increasing access to serum nutrients which then cross the vacuole membrane through a nutrient-permeable channel, supporting rapid parasite growth. This review highlights the most recent insights into the organization of the parasite vacuole to facilitate the solute, lipid and effector protein trafficking that establishes a nutrition pipeline in the terminally differentiated, organelle-free red blood cell.
Identifiants
pubmed: 34375857
pii: S1369-5274(21)00097-7
doi: 10.1016/j.mib.2021.07.010
pmc: PMC8463430
mid: NIHMS1727806
pii:
doi:
Substances chimiques
Protozoan Proteins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
181-188Subventions
Organisme : NHLBI NIH HHS
ID : K99 HL133453
Pays : United States
Organisme : NHLBI NIH HHS
ID : R00 HL133453
Pays : United States
Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.
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