Investigation of fatal human Borna disease virus 1 encephalitis outside the previously known area for human cases, Brandenburg, Germany - a case report.
BoDV-1
Bornavirus
Case report
Clinical awareness
Phylogeny
Journal
BMC infectious diseases
ISSN: 1471-2334
Titre abrégé: BMC Infect Dis
Pays: England
ID NLM: 100968551
Informations de publication
Date de publication:
10 Aug 2021
10 Aug 2021
Historique:
received:
07
07
2020
accepted:
15
07
2021
entrez:
11
8
2021
pubmed:
12
8
2021
medline:
25
9
2021
Statut:
epublish
Résumé
The true burden and geographical distribution of human Borna disease virus 1 (BoDV-1) encephalitis is unknown. All detected cases so far have been recorded in Bavaria, southern Germany. A retrospective laboratory and epidemiological investigation of a 2017 case of fatal encephalitis in a farmer in Brandenburg, northeast Germany, demonstrated BoDV-1 as causative agent by polymerase chain reaction, immunohistochemistry and in situ hybridization. Next-generation sequencing showed that the virus belonged to a cluster not known to be endemic in Brandenburg. The investigation was triggered by a recent outbreak of animal Borna disease in the region. Multiple possible exposures were identified. The next-of-kin were seronegative. The investigation highlights clinical awareness for human BoDV-1 encephalitis which should be extended to all areas endemic for animal Borna disease. All previously diagnosed human cases had occurred > 350 km further south. Further testing of shrews and livestock with Borna disease may show whether this BoDV-1 cluster is additionally endemic in the northwest of Brandenburg.
Sections du résumé
BACKGROUND
BACKGROUND
The true burden and geographical distribution of human Borna disease virus 1 (BoDV-1) encephalitis is unknown. All detected cases so far have been recorded in Bavaria, southern Germany.
CASE PRESENTATION
METHODS
A retrospective laboratory and epidemiological investigation of a 2017 case of fatal encephalitis in a farmer in Brandenburg, northeast Germany, demonstrated BoDV-1 as causative agent by polymerase chain reaction, immunohistochemistry and in situ hybridization. Next-generation sequencing showed that the virus belonged to a cluster not known to be endemic in Brandenburg. The investigation was triggered by a recent outbreak of animal Borna disease in the region. Multiple possible exposures were identified. The next-of-kin were seronegative.
CONCLUSIONS
CONCLUSIONS
The investigation highlights clinical awareness for human BoDV-1 encephalitis which should be extended to all areas endemic for animal Borna disease. All previously diagnosed human cases had occurred > 350 km further south. Further testing of shrews and livestock with Borna disease may show whether this BoDV-1 cluster is additionally endemic in the northwest of Brandenburg.
Identifiants
pubmed: 34376142
doi: 10.1186/s12879-021-06439-3
pii: 10.1186/s12879-021-06439-3
pmc: PMC8353434
doi:
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
787Subventions
Organisme : Bundesministerium für Bildung und Forschung
ID : 01KI1722A/C/E
Informations de copyright
© 2021. The Author(s).
Références
N Engl J Med. 2018 Oct 4;379(14):1377-1379
pubmed: 30281984
Emerg Infect Dis. 2021 May;27(5):1371-1379
pubmed: 33900167
Lancet Infect Dis. 2020 Apr;20(4):467-477
pubmed: 31924550
PLoS Pathog. 2019 Aug 1;15(8):e1007873
pubmed: 31369648
Emerg Microbes Infect. 2017 Jun 21;6(6):e52
pubmed: 28634359
Emerg Infect Dis. 2018 Jun;24(6):978-987
pubmed: 29774846
J Comp Pathol. 2010 Aug-Oct;143(2-3):203-8
pubmed: 20153871
Neuropathol Appl Neurobiol. 2008 Dec;34(6):590-602
pubmed: 18282160
N Engl J Med. 2015 Jul 9;373(2):154-62
pubmed: 26154788
Drugs. 2013 Feb;73(2):131-58
pubmed: 23377760
Acta Neuropathol. 2019 Jun;137(6):1017-1019
pubmed: 30953131
Acta Neuropathol. 2019 Oct;138(4):653-665
pubmed: 31346692
N Engl J Med. 2018 Oct 4;379(14):1375-1377
pubmed: 30281979
PLoS One. 2015 Aug 27;10(8):e0137018
pubmed: 26313904
J Gen Virol. 2005 Feb;86(Pt 2):385-398
pubmed: 15659758
PLoS One. 2014 Apr 03;9(4):e93659
pubmed: 24699636
Rev Med Virol. 2007 May-Jun;17(3):181-203
pubmed: 17342788
Transbound Emerg Dis. 2020 Mar 29;:
pubmed: 32223069
Vet Rec. 2011 Apr 9;168(14):380b
pubmed: 21498268