Clinic-based diabetes screening at the time of HIV testing and associations with poor clinical outcomes in South Africa: a cohort study.
Diabetes mellitus
HIV
Hyperglycemia
Mortality
Pre-diabetes
Tuberculosis
Journal
BMC infectious diseases
ISSN: 1471-2334
Titre abrégé: BMC Infect Dis
Pays: England
ID NLM: 100968551
Informations de publication
Date de publication:
10 Aug 2021
10 Aug 2021
Historique:
received:
24
07
2020
accepted:
09
07
2021
entrez:
11
8
2021
pubmed:
12
8
2021
medline:
25
9
2021
Statut:
epublish
Résumé
HIV clinical care programs in high burden settings are uniquely positioned to facilitate diabetes diagnosis, which is a major challenge. However, in sub-Saharan Africa, data on the burden of diabetes among people living with HIV (PLHIV) and its impact on HIV outcomes is sparse. We enrolled adults presenting for HIV testing at an outpatient clinic in Durban. Those who tested positive for HIV-infection were screened for diabetes using a point-of-care hemoglobin A Among 1369 PLHIV, 0.5% (n = 7) reported a prior diabetes diagnosis, 20.6% (95% CI 18.5-22.8%, n = 282) screened positive for pre-diabetes (HbA Diabetes and pre-diabetes were common among adults testing positive for HIV and associated with death. Clinic-based diabetes screening could be targeted to higher risk groups and may improve HIV treatment outcomes.
Sections du résumé
BACKGROUND
BACKGROUND
HIV clinical care programs in high burden settings are uniquely positioned to facilitate diabetes diagnosis, which is a major challenge. However, in sub-Saharan Africa, data on the burden of diabetes among people living with HIV (PLHIV) and its impact on HIV outcomes is sparse.
METHODS
METHODS
We enrolled adults presenting for HIV testing at an outpatient clinic in Durban. Those who tested positive for HIV-infection were screened for diabetes using a point-of-care hemoglobin A
RESULTS
RESULTS
Among 1369 PLHIV, 0.5% (n = 7) reported a prior diabetes diagnosis, 20.6% (95% CI 18.5-22.8%, n = 282) screened positive for pre-diabetes (HbA
CONCLUSIONS
CONCLUSIONS
Diabetes and pre-diabetes were common among adults testing positive for HIV and associated with death. Clinic-based diabetes screening could be targeted to higher risk groups and may improve HIV treatment outcomes.
Identifiants
pubmed: 34376173
doi: 10.1186/s12879-021-06473-1
pii: 10.1186/s12879-021-06473-1
pmc: PMC8353828
doi:
Substances chimiques
Anti-HIV Agents
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
789Subventions
Organisme : NIAID NIH HHS
ID : K23 AI108293
Pays : United States
Organisme : NIAID NIH HHS
ID : R03 AI143351
Pays : United States
Organisme : NIAID NIH HHS
ID : F31 AI138633
Pays : United States
Informations de copyright
© 2021. The Author(s).
Références
BMC Public Health. 2011 Jul 14;11:564
pubmed: 21756350
AIDS Patient Care STDS. 2012 Apr;26(4):197-201
pubmed: 22324292
Eur Respir J. 2017 Jul 20;50(1):
pubmed: 28729474
Bull World Health Organ. 2019 Jan 1;97(1):10-23
pubmed: 30618461
Acta Haematol. 2004;112(3):126-8
pubmed: 15345893
AIDS. 2018 Jan 14;32(2):253-260
pubmed: 29135581
J Acquir Immune Defic Syndr. 2017 Aug 15;75(5):561-567
pubmed: 28696346
Int J STD AIDS. 2019 Sep;30(10):991-998
pubmed: 31335273
Diabetes Care. 2018 Jan;41(Suppl 1):S13-S27
pubmed: 29222373
Lancet. 2017 Sep 16;390(10100):1151-1210
pubmed: 28919116
AIDS. 2018 Jul 1;32 Suppl 1:S33-S42
pubmed: 29952788
PLoS One. 2017 Oct 2;12(10):e0184264
pubmed: 28968435
PLoS One. 2011;6(8):e24215
pubmed: 21912626
BMC Infect Dis. 2015 Jan 17;15:20
pubmed: 25595711
Cancer. 1950 Jan;3(1):32-5
pubmed: 15405679
J Acquir Immune Defic Syndr. 2011 Aug 1;57(4):284-9
pubmed: 21602696
BMJ Open. 2017 Mar 29;7(3):e013953
pubmed: 28360243
J Infect Dis. 2016 Apr 1;213(7):1163-72
pubmed: 26609005
Postgrad Med. 2013 May;125(3):91-8
pubmed: 23748510
Diabetes Res Clin Pract. 2014 Feb;103(2):150-60
pubmed: 24300018
Clin Infect Dis. 2011 Dec;53(11):1120-6
pubmed: 21998278
AIDS Res Hum Retroviruses. 2016 Dec;32(12):1210-1218
pubmed: 27329066
Clin Chem Lab Med. 2017 Feb 1;55(2):167-180
pubmed: 27658148
PLoS Med. 2008 Jul 15;5(7):e152
pubmed: 18630984
Diabetes Res Clin Pract. 2016 Aug;118:1-11
pubmed: 27485851
BMC Res Notes. 2016 Aug 02;9:379
pubmed: 27484005
PLoS One. 2016 Aug 25;11(8):e0161966
pubmed: 27560687
Point Care. 2014 Dec;13(4):142-147
pubmed: 25593546
J Antimicrob Chemother. 2014 Dec;69(12):3360-7
pubmed: 25096078
Diabetes Metab Res Rev. 2017 Sep;33(6):
pubmed: 28437854
J Diabetes Res. 2018 May 23;2018:6916497
pubmed: 30009182
BMJ Open Diabetes Res Care. 2017 Jan 5;5(1):e000304
pubmed: 28191320
Diabetes Care. 2009 Sep;32(9):1591-3
pubmed: 19502538
AIDS. 2009 Jun 19;23(10):1227-34
pubmed: 19444074
AIDS. 2018 Jul 1;32 Suppl 1:S83-S92
pubmed: 29952794
Acad Emerg Med. 2008 Dec;15(12):1241-7
pubmed: 18785943
J Int AIDS Soc. 2019 Mar;22(3):e25213
pubmed: 30916897
Antivir Ther. 2010;15(4):571-7
pubmed: 20587850