Influenza vaccine acceptance and hesitancy among adults hospitalized with severe acute respiratory illnesses, United States 2019-2020.

Understanding patient factors associated with not being vaccinated is essential for successful implementation of influenza vaccination programs. We enrolled adults hospitalized with severe acute respiratory illness at 10 United States (US) hospitals during the 2019-2020 influenza season. We interviewed patients to collect data about influenza vaccination, sociodemographic characteristics, and vaccine perceptions. Among 679 participants, 264 (38.9%) reported not receiving influenza vaccination. Among those not vaccinated, 135 (51.1%) reported choosing not to receive a vaccine because of perceived ineffectiveness (36.7%) or risk (14.4%) of influenza vaccination. Sociodemographic factors associated with not being vaccinated included no medical insurance (aOR = 6.42; 95% CI: 2.52-16.38) and being non-White or Hispanic (aOR = 1.54, 95% CI: 1.02-2.32). Optimizing uptake of influenza vaccination in the US may be improved by educational programs regarding vaccine safety and effectiveness and enhancing vaccine access, particularly among non-White and Hispanic Americans and those without medical insurance.

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Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: [Dr. Brown reports grants from CDC, during the conduct of the study; personal fees from Hamilton, other from Faron, other from Sedana, grants from Janssen, grants from NIH, grants from DoD, other from Oxford University, other from Brigham Young University, outside the submitted work. Dr. Grijalva reports other from Pfizer, other from Merck, other from Sanofi-Pasteur, grants from Campbell Alliance, grants from Centers for Disease Control and Prevention, grants from National Institutes of Health, grants from Food and Drug Administration, grants from Agency for Health Care Research and Quality, grants from Sanofi, outside the submitted work. Dr. Files reports grants from CDC, during the conduct of the study; personal fees from Cytovale, personal fees from Medpace, outside the submitted work. Dr. Lindsell reports grants from CDC, during the conduct of the study; grants from NIH, grants from DoD, grants from CDC, other from Entegrion Inc., other from Endpoint LLC, other from bioMerieux, grants from Marcus Foundation, outside the submitted work. The other authors declare no potential competing interests.].