Integrated longitudinal immunophenotypic, transcriptional and repertoire analyses delineate immune responses in COVID-19 patients.
Adult
Aged
Antibodies, Viral
/ immunology
B-Lymphocytes
/ immunology
Biomarkers
COVID-19
/ genetics
Cell Plasticity
/ genetics
Clonal Evolution
/ immunology
Female
Gene Expression Profiling
Host-Pathogen Interactions
/ immunology
Humans
Immunoglobulin Isotypes
/ immunology
Immunologic Memory
Immunophenotyping
Leukocytes, Mononuclear
/ immunology
Lymphocyte Count
Male
Middle Aged
SARS-CoV-2
/ immunology
T-Lymphocyte Subsets
/ immunology
Transcriptome
Journal
Science immunology
ISSN: 2470-9468
Titre abrégé: Sci Immunol
Pays: United States
ID NLM: 101688624
Informations de publication
Date de publication:
10 08 2021
10 08 2021
Historique:
received:
11
01
2021
accepted:
04
08
2021
entrez:
11
8
2021
pubmed:
12
8
2021
medline:
21
8
2021
Statut:
ppublish
Résumé
To understand how a protective immune response against SARS-CoV-2 develops over time, we integrated phenotypic, transcriptional and repertoire analyses on PBMCs from mild and severe COVID-19 patients during and after infection, and compared them to healthy donors (HD). A type I IFN-response signature marked all the immune populations from severe patients during the infection. Humoral immunity was dominated by IgG production primarily against the RBD and N proteins, with neutralizing antibody titers increasing post infection and with disease severity. Memory B cells, including an atypical FCRL5
Identifiants
pubmed: 34376481
pii: 6/62/eabg5021
doi: 10.1126/sciimmunol.abg5021
pii:
doi:
Substances chimiques
Antibodies, Viral
0
Biomarkers
0
Immunoglobulin Isotypes
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2021, American Association for the Advancement of Science.