The continuity of effect of schizophrenia polygenic risk score and patterns of cannabis use on transdiagnostic symptom dimensions at first-episode psychosis: findings from the EU-GEI study.
Journal
Translational psychiatry
ISSN: 2158-3188
Titre abrégé: Transl Psychiatry
Pays: United States
ID NLM: 101562664
Informations de publication
Date de publication:
10 08 2021
10 08 2021
Historique:
received:
13
12
2020
accepted:
30
06
2021
revised:
16
06
2021
entrez:
11
8
2021
pubmed:
12
8
2021
medline:
12
10
2021
Statut:
epublish
Résumé
Diagnostic categories do not completely reflect the heterogeneous expression of psychosis. Using data from the EU-GEI study, we evaluated the impact of schizophrenia polygenic risk score (SZ-PRS) and patterns of cannabis use on the transdiagnostic expression of psychosis. We analysed first-episode psychosis patients (FEP) and controls, generating transdiagnostic dimensions of psychotic symptoms and experiences using item response bi-factor modelling. Linear regression was used to test the associations between these dimensions and SZ-PRS, as well as the combined effect of SZ-PRS and cannabis use on the dimensions of positive psychotic symptoms and experiences. We found associations between SZ-PRS and (1) both negative (B = 0.18; 95%CI 0.03-0.33) and positive (B = 0.19; 95%CI 0.03-0.35) symptom dimensions in 617 FEP patients, regardless of their categorical diagnosis; and (2) all the psychotic experience dimensions in 979 controls. We did not observe associations between SZ-PRS and the general and affective dimensions in FEP. Daily and current cannabis use were associated with the positive dimensions in FEP (B = 0.31; 95%CI 0.11-0.52) and in controls (B = 0.26; 95%CI 0.06-0.46), over and above SZ-PRS. We provide evidence that genetic liability to schizophrenia and cannabis use map onto transdiagnostic symptom dimensions, supporting the validity and utility of the dimensional representation of psychosis. In our sample, genetic liability to schizophrenia correlated with more severe psychosis presentation, and cannabis use conferred risk to positive symptomatology beyond the genetic risk. Our findings support the hypothesis that psychotic experiences in the general population have similar genetic substrates as clinical disorders.
Identifiants
pubmed: 34376640
doi: 10.1038/s41398-021-01526-0
pii: 10.1038/s41398-021-01526-0
pmc: PMC8355107
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
423Subventions
Organisme : Medical Research Council
ID : MR/L010305/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/M008436/1
Pays : United Kingdom
Organisme : Department of Health
Pays : United Kingdom
Investigateurs
Kathryn Hubbard
(K)
Stephanie Beards
(S)
Simona A Stilo
(SA)
Mara Parellada
(M)
David Fraguas
(D)
Marta Rapado Castro
(MR)
Álvaro Andreu-Bernabeu
(Á)
Gonzalo López
(G)
Mario Matteis
(M)
Emiliano González
(E)
Manuel Durán-Cutilla
(M)
Covadonga M Díaz-Caneja
(CM)
Pedro Cuadrado
(P)
José Juan Rodríguez Solano
(JJ)
Angel Carracedo
(A)
Javier Costas
(J)
Emilio Sánchez
(E)
Silvia Amoretti
(S)
Esther Lorente-Rovira
(E)
Paz Garcia-Portilla
(P)
Estela Jiménez-López
(E)
Nathalie Franke
(N)
Daniella van Dam
(D)
Fabian Termorshuizen
(F)
Nathalie Franke
(N)
Elsje van der Ven
(E)
Elles Messchaart
(E)
Marion Leboyer
(M)
Franck Schürhoff
(F)
Stéphane Jamain
(S)
Grégoire Baudin
(G)
Aziz Ferchiou
(A)
Baptiste Pignon
(B)
Jean-Romain Richard
(JR)
Thomas Charpeaud
(T)
Anne-Marie Tronche
(AM)
Flora Frijda
(F)
Giovanna Marrazzo
(G)
Lucia Sideli
(L)
Crocettarachele Sartorio
(C)
Fabio Seminerio
(F)
Camila Marcelino Loureiro
(CM)
Rosana Shuhama
(R)
Mirella Ruggeri
(M)
Chiara Bonetto
(C)
Doriana Cristofalo
(D)
Domenico Berardi
(D)
Marco Seri
(M)
Giuseppe D'Andrea
(G)
Informations de copyright
© 2021. The Author(s).
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