In silico characterisation of putative Plasmodium falciparum vaccine candidates in African malaria populations.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
10 08 2021
10 08 2021
Historique:
received:
12
11
2020
accepted:
09
07
2021
entrez:
11
8
2021
pubmed:
12
8
2021
medline:
9
11
2021
Statut:
epublish
Résumé
Genetic diversity of surface exposed and stage specific Plasmodium falciparum immunogenic proteins pose a major roadblock to developing an effective malaria vaccine with broad and long-lasting immunity. We conducted a prospective genetic analysis of candidate antigens (msp1, ama1, rh5, eba175, glurp, celtos, csp, lsa3, Pfsea, trap, conserved chrom3, hyp9, hyp10, phistb, surfin8.2, and surfin14.1) for malaria vaccine development on 2375 P. falciparum sequences from 16 African countries. We described signatures of balancing selection inferred from positive values of Tajima's D for all antigens across all populations except for glurp. This could be as a result of immune selection on these antigens as positive Tajima's D values mapped to regions with putative immune epitopes. A less diverse phistb antigen was characterised with a transmembrane domain, glycophosphatidyl anchors between the N and C- terminals, and surface epitopes that could be targets of immune recognition. This study demonstrates the value of population genetic and immunoinformatic analysis for identifying and characterising new putative vaccine candidates towards improving strain transcending immunity, and vaccine efficacy across all endemic populations.
Identifiants
pubmed: 34376744
doi: 10.1038/s41598-021-95442-4
pii: 10.1038/s41598-021-95442-4
pmc: PMC8355234
doi:
Substances chimiques
Antigens, Protozoan
0
Epitopes
0
Malaria Vaccines
0
Protozoan Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
16215Informations de copyright
© 2021. The Author(s).
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