Sex differences in risk factors for future onset of reflux esophagitis.
longitudinal study
real world evidence
reflux esophagitis
risk factors
sex differences
Journal
Journal of clinical biochemistry and nutrition
ISSN: 0912-0009
Titre abrégé: J Clin Biochem Nutr
Pays: Japan
ID NLM: 8700907
Informations de publication
Date de publication:
Jul 2021
Jul 2021
Historique:
received:
15
12
2020
accepted:
25
12
2020
entrez:
11
8
2021
pubmed:
12
8
2021
medline:
12
8
2021
Statut:
ppublish
Résumé
Reflux esophagitis is known to be more prevalent in males, and previous studies have suggested sex differences in its risk factors. However, little is known about sex differences in the time-course of risk factors before reflux esophagitis onset. Thus, we conducted a retrospective longitudinal study using health checkup records. From the records of 230,056 individuals obtained from nine institutes in Japan, we selected 1,558 male reflux esophagitis cases, 3,116 male controls, 508 female reflux esophagitis cases, and 1,016 female controls were selected. We compared time-courses of risk factors between the case and control groups and identified abdominal circumference (AC), diastolic blood pressure, alanine transaminase (ALT), and current smoking in males and body mass index (BMI) in females as sex-specific risk factors. We also found that AC and ALT in males and BMI in females were significantly different between the reflux esophagitis case and control groups during the five years before reflux esophagitis onset. Our results suggest that visceral fat-type obesity and fatty liver in males and higher BMI in females are more frequently observed in reflux esophagitis cases several years before reflux esophagitis onset, and that proactive intervention to lifestyle can help prevent reflux esophagitis in both males and females.
Identifiants
pubmed: 34376918
doi: 10.3164/jcbn.20-202
pii: DN/JST.JSTAGE/jcbn/20-202
pmc: PMC8325768
doi:
Types de publication
Journal Article
Langues
eng
Pagination
91-97Informations de copyright
Copyright © 2021 JCBN.
Déclaration de conflit d'intérêts
No potential conflicts of interest were disclosed.
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