A single-dose nitrate-producing dietary supplement affects cardiorespiratory endurance and muscular fitness in healthy men: A randomized controlled pilot trial.
Nitrate
blood pressure
ergogenic
time to exhaustion
Journal
SAGE open medicine
ISSN: 2050-3121
Titre abrégé: SAGE Open Med
Pays: England
ID NLM: 101624744
Informations de publication
Date de publication:
2021
2021
Historique:
received:
20
04
2021
accepted:
09
07
2021
entrez:
11
8
2021
pubmed:
12
8
2021
medline:
12
8
2021
Statut:
epublish
Résumé
The main aim of this pilot study was to examine the effects of a single-dose intervention with a novel nitrate-producing formulation (MagNOVOx™) on biomarkers of cardiorespiratory endurance and muscular fitness in 12 healthy men. The study participants (age = 22.7 ± 2.8 years, height = 184.1 ± 5.7 cm, and weight = 82.5 ± 8.4 kg) were randomly allocated to receive either a single dose of MagNOVOx™ or a placebo (inulin) in a cross-over design. The primary outcome for this study was the change in running time to exhaustion evaluated at baseline (before supplementation) and post-intervention. Time to exhaustion was improved after the intervention in 8 out of 11 participants (72.7%) who received MagNOVOx™, and in 1 out of 11 participants (9.1%) who received placebo ( These promising findings should be further corroborated in medium- and long-term trials, and different populations, while the exact mechanism of MagNOVOx™ requires additional physiological studies.
Identifiants
pubmed: 34377472
doi: 10.1177/20503121211036119
pii: 10.1177_20503121211036119
pmc: PMC8327001
doi:
Types de publication
Journal Article
Langues
eng
Pagination
20503121211036119Informations de copyright
© The Author(s) 2021.
Déclaration de conflit d'intérêts
Declaration of conflicting interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Références
FEBS Lett. 1994 Dec 19;356(2-3):295-8
pubmed: 7805858
J Am Coll Nutr. 2019 Nov-Dec;38(8):729-738
pubmed: 31084516
Appl Physiol Nutr Metab. 2016 Oct;41(10):1100-1103
pubmed: 27690568
Nutrients. 2015 Mar 12;7(3):1906-15
pubmed: 25774606
Nutr Res. 2015 Aug;35(8):643-54
pubmed: 26189149
J Cachexia Sarcopenia Muscle. 2019 Jun;10(3):601-610
pubmed: 30907070
Front Physiol. 2019 Apr 24;10:404
pubmed: 31068827
J Appl Physiol (1985). 2010 Jul;109(1):135-48
pubmed: 20466802
Am J Physiol Regul Integr Comp Physiol. 2010 Oct;299(4):R1121-31
pubmed: 20702806
Annu Rev Nutr. 2018 Aug 21;38:303-328
pubmed: 30130468
J Appl Physiol (1985). 2018 Dec 1;125(6):1997-2007
pubmed: 30359537
Am J Clin Nutr. 2020 Jan 1;111(1):79-89
pubmed: 31599928
J Physiol. 2012 Aug 1;590(15):3575-83
pubmed: 22687611
Int J Sports Physiol Perform. 2019 Oct 23;15(2):243-248
pubmed: 31172827