Extracellular Vesicles in neural cell interaction and CNS homeostasis.
axonal maintenance
blood–brain barrier
exosomes
in vivo imaging
microvesicles
neuroinflammation
neuron–glia interaction
synaptic plasticity
Journal
FASEB bioAdvances
ISSN: 2573-9832
Titre abrégé: FASEB Bioadv
Pays: United States
ID NLM: 101733210
Informations de publication
Date de publication:
Aug 2021
Aug 2021
Historique:
received:
06
03
2021
revised:
16
04
2021
accepted:
22
04
2021
entrez:
11
8
2021
pubmed:
12
8
2021
medline:
12
8
2021
Statut:
epublish
Résumé
Central nervous system (CNS) homeostasis critically depends on the interaction between neurons and glia cells. Extracellular vesicles (EVs) recently emerged as versatile messengers in CNS cell communication. EVs are released by neurons and glia in activity-dependent manner and address multiple target cells within and outside the nervous system. Here, we summarize the recent advances in understanding the physiological roles of EVs in the nervous system and their ability to deliver signals across the CNS barriers. In addition to the disposal of cellular components via EVs and clearance by phagocytic cells, EVs are involved in plasticity-associated processes, mediate trophic support and neuroprotection, promote axonal maintenance, and modulate neuroinflammation. While individual functional components of the EV cargo are becoming progressively identified, the role of neural EVs as compound multimodal signaling entities remains to be elucidated. Novel transgenic models and imaging technologies allow EV tracking in vivo and provide further insight into EV targeting and their mode of action. Overall, EVs represent key players in the maintenance of CNS homeostasis essential for the lifelong performance of neural networks and thus provide a wide spectrum of biomedical applications.
Identifiants
pubmed: 34377954
doi: 10.1096/fba.2021-00035
pii: FBA21234
pmc: PMC8332475
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
577-592Informations de copyright
© 2021 The Authors. FASEB BioAdvances published by the Federation of American Societies for Experimental Biology.
Déclaration de conflit d'intérêts
The authors declared that no conflict of interest exists.
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