Mutually Exclusive Expression of COL11A1 by CAFs and Tumour Cells in a Large panCancer and a Salivary Gland Carcinoma Cohort.
CAFs
COL11A1
Extracellular matrix
RNA-ISH
Salivary gland carcinoma
Tumour microenvironment
Journal
Head and neck pathology
ISSN: 1936-0568
Titre abrégé: Head Neck Pathol
Pays: United States
ID NLM: 101304010
Informations de publication
Date de publication:
Jun 2022
Jun 2022
Historique:
received:
14
06
2021
accepted:
26
07
2021
pubmed:
12
8
2021
medline:
15
6
2022
entrez:
11
8
2021
Statut:
ppublish
Résumé
Procollagen 11A1 (COL11A1) is a central component of the extracellular matrix in many carcinomas, which is considered to be mainly produced by cancer associated fibroblasts (CAFs). As COL11A1 expression correlates with adverse prognosis and is implicated in chemoresistance, it is a promising putative target. For the first time, we used RNA in-situ hybridization to systematically identify the cells that produce COL11A1 in the ten most prevalent carcinoma types, lymphomas (n = 275) and corresponding normal tissue (n = 55; panCancer cohort). Moreover, as most salivary gland carcinomas (SGC) display distinct stromal architectures, we also analysed 110 SGC. The corresponding protein formation of COL11A1 was determined by MALDI-TOF-MS-Imaging. We report that colon, breast and salivary duct carcinomas are highly infiltrated by COL11A1 positive CAFs (CAFs
Identifiants
pubmed: 34378164
doi: 10.1007/s12105-021-01370-0
pii: 10.1007/s12105-021-01370-0
pmc: PMC9187800
doi:
Substances chimiques
Biomarkers, Tumor
0
COL11A1 protein, human
0
Collagen Type XI
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
394-406Commentaires et corrections
Type : ErratumIn
Informations de copyright
© 2021. The Author(s).
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