Molecular imaging of cardiovascular inflammation.
CT
MRI
PET
atherosclerosis
heart
inflammation
molecular imaging
photoacoustic imaging (PAI)
surface-enhanced Raman spectroscopy (SERS)
Journal
British journal of pharmacology
ISSN: 1476-5381
Titre abrégé: Br J Pharmacol
Pays: England
ID NLM: 7502536
Informations de publication
Date de publication:
11 2021
11 2021
Historique:
revised:
22
10
2020
received:
27
06
2020
accepted:
09
11
2020
pubmed:
12
8
2021
medline:
15
12
2021
entrez:
11
8
2021
Statut:
ppublish
Résumé
Cardiovascular diseases (CVDs), including atherosclerosis, are chronic inflammatory diseases characterised by a complex and evolving tissue micro-environment. Molecular heterogeneity of inflammatory responses translates into clinical outcomes. However, current medical imaging modalities are unable to reveal the cellular and molecular events at a level of detail that would allow more accurate and timely diagnosis and treatment. This is an inherent limitation of the current imaging tools, which are restricted to anatomical or functional data. Molecular imaging-the visualisation and quantification of molecules in the body-is already established in the clinic in the form of PET, yet the use of PET in CVD is limited. In this visual review, we will guide you through the current state of molecular imaging research, assessing the respective strengths and weaknesses of molecular imaging modalities, including those already being used in the clinic such as PET and MRI and emerging technologies at preclinical stage, such as photoacoustic imaging. We discuss the basic principles of each technology and provide key examples of their application in imaging inflammation in CVD and the added value into the diagnostic decision-making process. Finally, we discuss the barriers to the rapid successful clinical translation of these novel diagnostic modalities. LINKED ARTICLES: This article is part of a themed issue on Molecular imaging - visual themed issue. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v178.21/issuetoc.
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
4216-4245Subventions
Organisme : British Heart Foundation
ID : PG/12/81/29897
Pays : United Kingdom
Organisme : British Heart Foundation
ID : PG/19/84/34771
Pays : United Kingdom
Organisme : British Heart Foundation
ID : RE/13/5/30177
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 204820/Z/16/Z
Pays : United Kingdom
Informations de copyright
© 2021 The British Pharmacological Society.
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