Association between tooth agenesis and cancer: a systematic review.
Journal
Journal of applied oral science : revista FOB
ISSN: 1678-7765
Titre abrégé: J Appl Oral Sci
Pays: Brazil
ID NLM: 101189774
Informations de publication
Date de publication:
2021
2021
Historique:
received:
23
11
2020
accepted:
06
04
2021
entrez:
11
8
2021
pubmed:
12
8
2021
medline:
13
8
2021
Statut:
epublish
Résumé
The congenital absence of multiple teeth may share the same genetic background of the development of some types of cancer. This systematic review aimed to investigate the possible association between dental agenesis and cancer, and the perspective of agenesis as an early predictor for cancer risk. The electronic databases PubMed, Scopus, Web of Science, Cochrane Library, LILACS, and OpenGrey were searched and the risk of bias was evaluated using the Newcastle-Ottawa tool. The GRADE tool was used to evaluate the certainty of the evidence. Six studies met the eligibility criteria. A positive co-occurrence between ovarian cancer and hypodontia was found in two articles. Three studies evaluated the association between dental agenesis and colorectal cancer and only one showed common genes for these conditions. One paper found individuals with hypodontia had a higher risk of family history of cancer. Five studies had a fair quality and one a good quality. The certainty of evidence was classified as very low. Notwithstanding the limited scientific evidence, there may be a possible association between dental agenesis and cancer due to genes involved in both conditions. Agenesis of multiple teeth could be an early indicator of cancer risk. Nevertheless, studies with a better level of evidence are needed to confirm this possible association.
Identifiants
pubmed: 34378652
pii: S1678-77572021000100802
doi: 10.1590/1678-7757-2020-0955
pmc: PMC8360625
pii:
doi:
Types de publication
Journal Article
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
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