Mechanistic Duality of Bacterial Efflux Substrates and Inhibitors: Example of Simple Substituted Cinnamoyl and Naphthyl Amides.
AcrAB−TolC
Escherichia coli
antibiotic permeation
antibiotic potentiation
efflux pump inhibitors
Journal
ACS infectious diseases
ISSN: 2373-8227
Titre abrégé: ACS Infect Dis
Pays: United States
ID NLM: 101654580
Informations de publication
Date de publication:
10 09 2021
10 09 2021
Historique:
pubmed:
12
8
2021
medline:
21
9
2021
entrez:
11
8
2021
Statut:
ppublish
Résumé
Antibiotic resistance poses an immediate and growing threat to human health. Multidrug efflux pumps are promising targets for overcoming antibiotic resistance with small-molecule therapeutics. Previously, we identified a diaminoquinoline acrylamide, NSC-33353, as a potent inhibitor of the AcrAB-TolC efflux pump in
Identifiants
pubmed: 34379382
doi: 10.1021/acsinfecdis.1c00100
pmc: PMC8668026
mid: NIHMS1761129
doi:
Substances chimiques
AcrB protein, E coli
0
Amides
0
Escherichia coli Proteins
0
Multidrug Resistance-Associated Proteins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
2650-2665Subventions
Organisme : NIAID NIH HHS
ID : R01 AI052293
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI136799
Pays : United States
Organisme : NIAID NIH HHS
ID : R56 AI052293
Pays : United States
Organisme : NIH HHS
ID : S10 OD025014
Pays : United States
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