IFN-γ Drives TNF-α Hyperproduction and Lethal Lung Inflammation during Antibiotic Treatment of Postinfluenza
Animals
Anti-Bacterial Agents
/ therapeutic use
Cells, Cultured
Humans
Inflammation
/ immunology
Influenza A virus
/ physiology
Influenza, Human
/ complications
Interferon-gamma
/ metabolism
Lung
/ immunology
Mice
Mice, Inbred C57BL
Mice, Knockout
Orthomyxoviridae Infections
/ complications
Pneumonia, Staphylococcal
/ complications
Staphylococcal Infections
/ complications
Staphylococcus aureus
/ physiology
Superinfection
Tumor Necrosis Factor-alpha
Journal
Journal of immunology (Baltimore, Md. : 1950)
ISSN: 1550-6606
Titre abrégé: J Immunol
Pays: United States
ID NLM: 2985117R
Informations de publication
Date de publication:
01 09 2021
01 09 2021
Historique:
received:
05
04
2021
accepted:
29
06
2021
pubmed:
13
8
2021
medline:
7
9
2021
entrez:
12
8
2021
Statut:
ppublish
Résumé
Inflammatory cytokine storm is a known cause for acute respiratory distress syndrome. In this study, we have investigated the role of IFN-γ in lethal lung inflammation using a mouse model of postinfluenza methicillin-resistant
Identifiants
pubmed: 34380647
pii: jimmunol.2100328
doi: 10.4049/jimmunol.2100328
doi:
Substances chimiques
Anti-Bacterial Agents
0
Tumor Necrosis Factor-alpha
0
Interferon-gamma
82115-62-6
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1371-1376Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL118408
Pays : United States
Organisme : NIAID NIH HHS
ID : R56 AI137161
Pays : United States
Informations de copyright
Copyright © 2021 by The American Association of Immunologists, Inc.