Multicentre observational study on practice of ventilation in brain injured patients: the VENTIBRAIN study protocol.
adult intensive & critical care
neurological injury
neurophysiology
Journal
BMJ open
ISSN: 2044-6055
Titre abrégé: BMJ Open
Pays: England
ID NLM: 101552874
Informations de publication
Date de publication:
11 08 2021
11 08 2021
Historique:
entrez:
12
8
2021
pubmed:
13
8
2021
medline:
14
8
2021
Statut:
epublish
Résumé
Mechanical ventilatory is a crucial element of acute brain injured patients' management. The ventilatory goals to ensure lung protection during acute respiratory failure may not be adequate in case of concomitant brain injury. Therefore, there are limited data from which physicians can draw conclusions regarding optimal ventilator management in this setting. This is an international multicentre prospective observational cohort study. The aim of the 'multicentre observational study on practice of ventilation in brain injured patients'-the VENTIBRAIN study-is to describe the current practice of ventilator settings and mechanical ventilation in acute brain injured patients. Secondary objectives include the description of ventilator settings among different countries, and their association with outcomes. Inclusion criteria will be adult patients admitted to the intensive care unit (ICU) with a diagnosis of traumatic brain injury or cerebrovascular diseases (intracranial haemorrhage, subarachnoid haemorrhage, ischaemic stroke), requiring intubation and mechanical ventilation and admission to the ICU. Exclusion criteria will be the following: patients aged <18 years; pregnant patients; patients not intubated or not mechanically ventilated or receiving only non-invasive ventilation. Data related to clinical examination, neuromonitoring if available, ventilator settings and arterial blood gases will be recorded at admission and daily for the first 7 days and then at day 10 and 14. The Glasgow Outcome Scale Extended on mortality and neurological outcome will be collected at discharge from ICU, hospital and at 6 months follow-up. The study has been approved by the Ethic committee of Brianza at the Azienda Socio Sanitaria Territoriale-Monza. Data will be disseminated to the scientific community by abstracts submitted to the European Society of Intensive Care Medicine annual conference and by original articles submitted to peer-reviewed journals. NCT04459884.
Identifiants
pubmed: 34380722
pii: bmjopen-2020-047100
doi: 10.1136/bmjopen-2020-047100
pmc: PMC8359464
doi:
Banques de données
ClinicalTrials.gov
['NCT04459884']
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e047100Investigateurs
Maura Mandelli
(M)
Jordi Mancebo
(J)
Robert Stevens
(R)
Geert Meyfroidt
(G)
Rafael Badenes
(R)
Valentina Della Torre
(VD)
Raimund Helbok
(R)
Jose' Suarez
(J)
Nino Stocchetti
(N)
Marcelo Gama De Abreu
(MG)
Marcus Schultz
(M)
Raphael Cinotti
(R)
Louis Blanch
(L)
Karim Asehnoune
(K)
Christian Putensen
(C)
John Laffey
(J)
Informations de copyright
© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
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