Diabetes mellitus and Parkinson's disease: dangerous liaisons between insulin and dopamine.
GLP-1
Parkinson’s disease
dopamine
insulin
type 2 diabetes mellitus
Journal
Neural regeneration research
ISSN: 1673-5374
Titre abrégé: Neural Regen Res
Pays: India
ID NLM: 101316351
Informations de publication
Date de publication:
Mar 2022
Mar 2022
Historique:
entrez:
12
8
2021
pubmed:
13
8
2021
medline:
13
8
2021
Statut:
ppublish
Résumé
The relationship between diabetes mellitus and Parkinson's disease has been described in several epidemiological studies over the 1960s to date. Molecular studies have shown the possible functional link between insulin and dopamine, as there is strong evidence demonstrating the action of dopamine in pancreatic islets, as well as the insulin effects on feeding and cognition through central nervous system mechanism, largely independent of glucose utilization. Therapies used for the treatment of type 2 diabetes mellitus appear to be promising candidates for symptomatic and/or disease-modifying action in neurodegenerative diseases including Parkinson's disease, while an old dopamine agonist, bromocriptine, has been repositioned for the type 2 diabetes mellitus treatment. This review will aim at reappraising the different studies that have highlighted the dangerous liaisons between diabetes mellitus and Parkinson's disease.
Identifiants
pubmed: 34380882
pii: NeuralRegenRes_2022_17_3_523_320965
doi: 10.4103/1673-5374.320965
pmc: PMC8504381
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
523-533Déclaration de conflit d'intérêts
None
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