Role of microtubule dynamics in Wallerian degeneration and nerve regeneration after peripheral nerve injury.
Schwann cell
Wallerian degeneration
axon
demyelination
microtubule dynamics
nerve regeneration
nocodazole
paclitaxel
peripheral nerve injury
Journal
Neural regeneration research
ISSN: 1673-5374
Titre abrégé: Neural Regen Res
Pays: India
ID NLM: 101316351
Informations de publication
Date de publication:
Mar 2022
Mar 2022
Historique:
entrez:
12
8
2021
pubmed:
13
8
2021
medline:
13
8
2021
Statut:
ppublish
Résumé
Wallerian degeneration, the progressive disintegration of distal axons and myelin that occurs after peripheral nerve injury, is essential for creating a permissive microenvironment for nerve regeneration, and involves cytoskeletal reconstruction. However, it is unclear whether microtubule dynamics play a role in this process. To address this, we treated cultured sciatic nerve explants, an in vitro model of Wallerian degeneration, with the microtubule-targeting agents paclitaxel and nocodazole. We found that paclitaxel-induced microtubule stabilization promoted axon and myelin degeneration and Schwann cell dedifferentiation, whereas nocodazole-induced microtubule destabilization inhibited these processes. Evaluation of an in vivo model of peripheral nerve injury showed that treatment with paclitaxel or nocodazole accelerated or attenuated axonal regeneration, as well as functional recovery of nerve conduction and target muscle and motor behavior, respectively. These results suggest that microtubule dynamics participate in peripheral nerve regeneration after injury by affecting Wallerian degeneration. This study was approved by the Animal Care and Use Committee of Southern Medical University, China (approval No. SMU-L2015081) on October 15, 2015.
Identifiants
pubmed: 34380909
pii: NeuralRegenRes_2022_17_3_673_320997
doi: 10.4103/1673-5374.320997
pmc: PMC8504388
doi:
Types de publication
Journal Article
Langues
eng
Pagination
673-681Déclaration de conflit d'intérêts
None
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