Dietary carbohydrate, particularly glucose, drives B cell lymphopoiesis and function.
Biological sciences
Cell biology
Developmental biology
Immunology
Journal
iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038
Informations de publication
Date de publication:
20 Aug 2021
20 Aug 2021
Historique:
received:
16
11
2020
revised:
15
06
2021
accepted:
07
07
2021
entrez:
12
8
2021
pubmed:
13
8
2021
medline:
13
8
2021
Statut:
epublish
Résumé
While diet modulates immunity, its impact on B cell ontogeny remains unclear. Using mixture modeling, a large-scale isocaloric dietary cohort mouse study identified carbohydrate as a major driver of B cell development and function. Increasing dietary carbohydrate increased B cell proportions in spleen, mesenteric lymph node and Peyer's patches, and increased antigen-specific immunoglobulin G production after immunization. This was linked to increased B lymphopoiesis in the bone marrow. Glucose promoted early B lymphopoiesis and higher total B lymphocyte numbers than fructose. It drove B cell development through glycolysis and oxidative phosphorylation, independently of fatty acid oxidation
Identifiants
pubmed: 34381967
doi: 10.1016/j.isci.2021.102835
pii: S2589-0042(21)00803-8
pmc: PMC8333167
doi:
Types de publication
Journal Article
Langues
eng
Pagination
102835Informations de copyright
© 2021 The Authors.
Déclaration de conflit d'intérêts
The authors declare no competing interests.
Références
Proc Natl Acad Sci U S A. 2012 May 15;109(20):7622-9
pubmed: 22538809
Mol Psychiatry. 2015 Jun;20(6):661-70
pubmed: 25687772
Sci Signal. 2019 Oct 22;12(604):
pubmed: 31641080
Clin Exp Immunol. 2019 Aug;197(2):237-249
pubmed: 30919933
JCI Insight. 2021 Apr 8;6(7):
pubmed: 33729999
J Hematol Oncol. 2019 Jul 5;12(1):71
pubmed: 31277692
Nat Immunol. 2020 Mar;21(3):331-342
pubmed: 32066950
PLoS One. 2014 Mar 04;9(3):e90639
pubmed: 24595332
J Immunol. 2017 Jun 15;198(12):4738-4752
pubmed: 28500069
Genome Res. 2002 Jan;12(1):98-111
pubmed: 11779835
Nat Rev Immunol. 2016 Sep;16(9):553-65
pubmed: 27396447
Cell. 2020 Jun 11;181(6):1263-1275.e16
pubmed: 32437658
Autoimmunity. 1989;4(1-2):109-14
pubmed: 2562379
J Pharmacol Sci. 2009 Apr;109(4):496-503
pubmed: 19372632
Int J Mol Sci. 2018 Jul 27;19(8):
pubmed: 30060475
EBioMedicine. 2018 Oct;36:293-303
pubmed: 30292675
Obesity (Silver Spring). 2020 Apr;28(4):822-829
pubmed: 32144892
J Exp Med. 2011 Jul 4;208(7):1367-76
pubmed: 21708926
Nutrients. 2021 Mar 02;13(3):
pubmed: 33801480
J Exp Med. 2018 Feb 5;215(2):399-413
pubmed: 29326381
J Clin Invest. 2009 Dec;119(12):3519-29
pubmed: 19959876
Nat Immunol. 2017 Mar;18(3):303-312
pubmed: 28114292
Proc Natl Acad Sci U S A. 2014 Jul 1;111(26):9573-8
pubmed: 24979759
Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15545-50
pubmed: 16199517
Trends Biochem Sci. 2006 Jun;31(6):342-8
pubmed: 16679021
Immunity. 2016 Jul 19;45(1):60-73
pubmed: 27396958
J Immunol. 2014 Apr 15;192(8):3626-36
pubmed: 24616478
J Immunol. 2007 Sep 15;179(6):3662-71
pubmed: 17785802
J Immunol. 2010 Jan 1;184(1):154-63
pubmed: 19949104
Epilepsia. 2011 Mar;52(3):e7-11
pubmed: 21371020
Nat Commun. 2017 Nov 13;8(1):1457
pubmed: 29133930
Cell Metab. 2014 Mar 4;19(3):418-30
pubmed: 24606899
J Biol Chem. 2014 Mar 7;289(10):7011-7024
pubmed: 24469453
Semin Immunol. 2012 Jun;24(3):198-208
pubmed: 22421572
J Immunol Res. 2017;2017:4807853
pubmed: 28484723
PLoS One. 2014 Feb 04;9(2):e87772
pubmed: 24504160
Blood. 2007 Mar 15;109(6):2339-45
pubmed: 17119110
Cell Death Differ. 2017 Jul;24(7):1239-1252
pubmed: 28524857
Nat Rev Immunol. 2006 Feb;6(2):107-16
pubmed: 16491135