DNA replication: the recombination connection.
alternative lengthening of telomeres (ALT)
break-induced replication (BIR)
homologous recombination
mitotic DNA synthesis (MiDAS)
Journal
Trends in cell biology
ISSN: 1879-3088
Titre abrégé: Trends Cell Biol
Pays: England
ID NLM: 9200566
Informations de publication
Date de publication:
01 2022
01 2022
Historique:
received:
07
06
2021
revised:
18
07
2021
accepted:
20
07
2021
pubmed:
14
8
2021
medline:
25
3
2022
entrez:
13
8
2021
Statut:
ppublish
Résumé
Failure to complete DNA replication is one of the major sources of genome instability leading to aneuploidy, chromosome breakage, and chromosome rearrangements that are associated with human cancer. One of the surprising revelations of the past decade is that the completion of replication at so-called common fragile sites (CFS) occurs very late in the cell cycle - at mitosis - through a process termed MiDAS (mitotic DNA synthesis). MiDAS is strongly related to another cancer-promoting phenomenon: the activation of alternative lengthening of telomeres (ALT). Our understanding of the mechanisms of ALT and MiDAS in mammalian cells has drawn heavily from recent advances in the study of break-induced replication (BIR), especially in budding yeast. We provide new insights into the BIR, MiDAS, and ALT pathways and their shared similarities.
Identifiants
pubmed: 34384659
pii: S0962-8924(21)00145-8
doi: 10.1016/j.tcb.2021.07.005
pmc: PMC8688190
mid: NIHMS1728011
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
45-57Subventions
Organisme : NIGMS NIH HHS
ID : R35 GM127029
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM076020
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM061766
Pays : United States
Organisme : NIGMS NIH HHS
ID : R37 GM020056
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM020056
Pays : United States
Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no competing interests.
Références
Nat Struct Mol Biol. 2014 Feb;21(2):167-74
pubmed: 24413054
Cancer Res. 1999 Sep 1;59(17):4175-9
pubmed: 10485449
Cell Rep. 2016 Feb 9;14(5):1032-1040
pubmed: 26832416
Nat Commun. 2019 May 28;10(1):2253
pubmed: 31138795
Nature. 2007 Aug 16;448(7155):820-3
pubmed: 17671506
Mol Cell. 2017 Feb 2;65(3):515-526.e3
pubmed: 28065599
Nature. 2015 Dec 10;528(7581):286-90
pubmed: 26633632
Science. 2021 Apr 23;372(6540):371-378
pubmed: 33888635
Neurology. 2021 Feb 16;96(7):e1054-e1062
pubmed: 33443126
Genes Dev. 2019 Feb 1;33(3-4):221-235
pubmed: 30692206
Cell. 2015 Dec 17;163(7):1641-54
pubmed: 26687355
Trends Biochem Sci. 1999 Jul;24(7):271-5
pubmed: 10390616
Cell. 1993 Apr 23;73(2):347-60
pubmed: 8477448
Cell Rep. 2020 Sep 22;32(12):108177
pubmed: 32966795
EMBO Rep. 2020 Jul 3;21(7):e49367
pubmed: 32419301
Cell Rep. 2014 May 22;7(4):1048-55
pubmed: 24813886
EMBO Rep. 2020 Jun 4;21(6):e49495
pubmed: 32337843
Science. 2018 Feb 9;359(6376):
pubmed: 29348367
DNA Repair (Amst). 2017 Nov;59:76-81
pubmed: 28963981
DNA Repair (Amst). 2021 Apr;100:103055
pubmed: 33581499
Science. 2015 Aug 14;349(6249):742-7
pubmed: 26273056
Cell Res. 2020 Nov;30(11):997-1008
pubmed: 32561860
Genetics. 1999 May;152(1):143-52
pubmed: 10224249
Nat Commun. 2017 Jul 17;8:15983
pubmed: 28714477
Cell Cycle. 2016 Aug 17;15(16):2099-2100
pubmed: 27384604
Nat Struct Mol Biol. 2020 Dec;27(12):1152-1164
pubmed: 33046907
J Biol Chem. 2020 Nov 6;295(45):15378-15397
pubmed: 32873711
DNA Repair (Amst). 2013 Mar 1;12(3):238-45
pubmed: 23347616
Nat Commun. 2021 Jan 21;12(1):512
pubmed: 33479235
Nat Commun. 2021 Feb 10;12(1):923
pubmed: 33568651
Elife. 2019 Sep 23;8:
pubmed: 31545170
Nature. 2013 Oct 17;502(7471):393-6
pubmed: 24025768
EMBO Rep. 2016 Dec;17(12):1731-1737
pubmed: 27760777
Genes Dev. 2020 Oct 1;34(19-20):1392-1405
pubmed: 32883681
Nucleic Acids Res. 2021 May 21;49(9):4831-4847
pubmed: 33744934
Cell Rep. 2019 Jan 22;26(4):955-968.e3
pubmed: 30673617
Cancers (Basel). 2019 Sep 29;11(10):
pubmed: 31569559
Trends Genet. 2021 Jul;37(7):639-656
pubmed: 33896583
Nat Commun. 2019 May 28;10(1):2252
pubmed: 31138797
Mol Biol Cell. 2020 Aug 15;31(18):2048-2056
pubmed: 32579423
Proc Natl Acad Sci U S A. 2020 Jul 14;117(28):16527-16536
pubmed: 32601218
Mol Cell Biol. 2002 Sep;22(18):6384-92
pubmed: 12192038
Proc Natl Acad Sci U S A. 1993 Apr 15;90(8):3363-7
pubmed: 8475081
Genes Dev. 2010 Jun 1;24(11):1133-44
pubmed: 20516198
PLoS Genet. 2020 Oct 15;16(10):e1008689
pubmed: 33057349
Front Cell Dev Biol. 2021 Apr 01;9:668171
pubmed: 33869233
Mol Cell Biol. 2001 Mar;21(6):2048-56
pubmed: 11238940
PLoS Biol. 2011 Feb 15;9(2):e1000594
pubmed: 21347245
Nat Biotechnol. 2009 Dec;27(12):1181-5
pubmed: 19935656
Genetics. 2014 Nov;198(3):795-835
pubmed: 25381364
Trends Genet. 2016 Sep;32(9):566-575
pubmed: 27450436
PLoS Genet. 2019 Feb 4;15(2):e1007925
pubmed: 30716077
Nat Commun. 2020 May 8;11(1):2267
pubmed: 32385287
Science. 2014 Jan 3;343(6166):88-91
pubmed: 24310611
Proc Natl Acad Sci U S A. 1996 Jul 9;93(14):7131-6
pubmed: 8692957
Genes Dev. 2019 Jul 1;33(13-14):814-827
pubmed: 31171703
Nucleic Acids Res. 2017 Sep 6;45(15):8886-8900
pubmed: 28911102
Nat Commun. 2018 Feb 27;9(1):858
pubmed: 29487291
Aging (Albany NY). 2021 Apr 4;13(7):10490-10516
pubmed: 33820871
Nature. 2016 Nov 3;539(7627):54-58
pubmed: 27760120
Nucleic Acids Res. 2020 Dec 16;48(22):12697-12710
pubmed: 33264397
Nucleic Acids Res. 2019 Oct 10;47(18):9666-9684
pubmed: 31392335
EMBO J. 2021 Apr 15;40(8):e104509
pubmed: 33470420
Genes Dev. 2014 Nov 1;28(21):2394-406
pubmed: 25367035
Cell Res. 2020 Nov;30(11):1009-1023
pubmed: 32561861
Nat Struct Mol Biol. 2020 May;27(5):424-437
pubmed: 32398827
Nucleic Acids Res. 2017 Mar 17;45(5):2615-2628
pubmed: 28082393
J Biol Chem. 2018 Jul 6;293(27):10524-10535
pubmed: 29599286
Mol Cell. 2021 Jun 3;81(11):2428-2444.e6
pubmed: 33882298
EMBO J. 2021 May 17;40(10):e104847
pubmed: 33844333
Annu Rev Genet. 2016 Nov 23;50:1-28
pubmed: 27732795
PLoS Biol. 2020 Jan 2;18(1):e3000594
pubmed: 31895940
Nature. 2007 May 3;447(7140):102-5
pubmed: 17410126
Mol Cell. 2021 Feb 18;81(4):811-829.e6
pubmed: 33529595
Mol Cell. 2021 Mar 4;81(5):1027-1042.e4
pubmed: 33453166
Nat Commun. 2020 Oct 20;11(1):5297
pubmed: 33082350
Cell Rep. 2016 May 10;15(6):1242-53
pubmed: 27134164
Proc Natl Acad Sci U S A. 2013 Aug 13;110(33):13475-80
pubmed: 23898170
Crit Rev Biochem Mol Biol. 2016 May-Jun;51(3):195-212
pubmed: 27098756
Nature. 2012 Jan 18;482(7383):53-8
pubmed: 22258507
Mol Cell. 2016 Dec 15;64(6):1117-1126
pubmed: 27984745
Mol Cell. 2021 Apr 15;81(8):1816-1829.e5
pubmed: 33639094
Nature. 2021 Feb;590(7847):655-659
pubmed: 33473214
Sci Rep. 2019 Dec 13;9(1):19110
pubmed: 31836759
iScience. 2021 Feb 25;24(3):102231
pubmed: 33748714
J Cell Biol. 2013 Apr 29;201(3):395-408
pubmed: 23609533
Nature. 2013 Oct 17;502(7471):389-92
pubmed: 24025772
Mol Cell Biol. 2007 Apr;27(7):2601-14
pubmed: 17242181
Methods Mol Biol. 2019;1999:31-57
pubmed: 31127568
Genes Dev. 2020 May 1;34(9-10):650-662
pubmed: 32217664
Nat Rev Mol Cell Biol. 2019 Nov;20(11):698-714
pubmed: 31263220
Curr Biol. 2001 Jan 23;11(2):125-9
pubmed: 11231130