Pericytes cross-talks within the tumor microenvironment.

Humans Pericytes / metabolism Tumor Microenvironment / immunology
Genetic depletion Metastatic niche Pericytes Tumor microenvironment β3 integrin

Journal

Biochimica et biophysica acta. Reviews on cancer
ISSN: 1879-2561
Titre abrégé: Biochim Biophys Acta Rev Cancer
Pays: Netherlands
ID NLM: 9806362

Informations de publication

Date de publication:
12 2021
Historique:
received: 13 10 2020
revised: 14 07 2021
accepted: 05 08 2021
pubmed: 14 8 2021
medline: 15 12 2021
entrez: 13 8 2021
Statut: ppublish

Résumé

Cancer cells are embedded within the tumor microenvironment and interact dynamically with its components during tumor progression. Understanding the molecular mechanisms by which the tumor microenvironment components communicate is crucial for the success of therapeutic applications. Recent studies show, by using state-of-the-art technologies, including sophisticated in vivo inducible Cre/loxP mediated systems and CRISPR-Cas9 gene editing, that pericytes communicate with cancer cells. The arising knowledge on cross-talks within the tumor microenvironment will be essential for the development of new therapies against cancer. Here, we review recent progress in our understanding of pericytes roles within tumors.

Identifiants

DOI: 10.1016/j.bbcan.2021.188608 PMID: 34384850
pubmed: 34384850
pii: S0304-419X(21)00105-0
doi: 10.1016/j.bbcan.2021.188608
pii:
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

188608

Informations de copyright

Copyright © 2021 Elsevier B.V. All rights reserved.

Auteurs

Caroline C Picoli (CC)

Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.

Bryan Ô P Gonçalves (BÔP)

Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.

Gabryella S P Santos (GSP)

Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.

Beatriz G S Rocha (BGS)

Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.

Alinne C Costa (AC)

Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.

Rodrigo R Resende (RR)

Department of Biochemistry and Immunology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.

Alexander Birbrair (A)

Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil; Department of Radiology, Columbia University Medical Center, New York, NY, USA. Electronic address: birbrair@icb.ufmg.br.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Pericytes cross-talks within the tumor...
questionsmedicales.fr › Structures de l'embryon › Feuillets embryonnaires › Mésoderme › Péricytes › Pericytes cross-talks within the tumor...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Microenvironnement cellulaire › Microenvironnement tumoral › Pericytes cross-talks within the tumor...