Cancer immunotherapy: A comprehensive appraisal of its modes of application.
adoptive cell transfer
cytokines
immune checkpoint inhibitors
monoclonal antibodies
vaccines
Journal
Oncology letters
ISSN: 1792-1082
Titre abrégé: Oncol Lett
Pays: Greece
ID NLM: 101531236
Informations de publication
Date de publication:
Sep 2021
Sep 2021
Historique:
received:
28
01
2021
accepted:
18
06
2021
entrez:
13
8
2021
pubmed:
14
8
2021
medline:
14
8
2021
Statut:
ppublish
Résumé
Conventional cancer treatments such as chemotherapy and radiation therapy have reached their therapeutic potential, leaving a gap for developing more effective cancer therapeutics. Cancer cells evade the immune system using various mechanisms of immune tolerance, underlying the potential impact of immunotherapy in the treatment of cancer. Immunotherapy includes several approaches such as activating the immune system in a cytokine-dependent manner, manipulating the feedback mechanisms involved in the immune response, enhancing the immune response via lymphocyte expansion and using cancer vaccines to elicit long-lasting, robust responses. These techniques can be used as monotherapies or combination therapies. The present review describes the immune-based mechanisms involved in tumor cell proliferation and maintenance and the rationale underlying various treatment methods. In addition, the present review provides insight into the potential of immunotherapy used alone or in combination with various types of therapeutics.
Identifiants
pubmed: 34386077
doi: 10.3892/ol.2021.12916
pii: OL-0-0-12916
pmc: PMC8299024
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
655Informations de copyright
Copyright © 2021, Spandidos Publications.
Déclaration de conflit d'intérêts
The authors declare that they have no competing interests.
Références
Cancer Immun. 2006 Mar 22;6:6
pubmed: 16551058
J Immunol. 2014 Jun 15;192(12):5451-8
pubmed: 24907378
Proc Natl Acad Sci U S A. 2006 Jun 13;103(24):9166-71
pubmed: 16757567
Mol Ther. 2019 Feb 6;27(2):314-325
pubmed: 30554854
Lancet Oncol. 2019 Mar;20(3):371-382
pubmed: 30765258
Clin Cancer Res. 2006 Dec 15;12(24):7437-43
pubmed: 17189417
Nature. 1995 Sep 28;377(6547):348-51
pubmed: 7566090
Mol Ther. 2019 Jun 5;27(6):1114-1125
pubmed: 30962163
N Engl J Med. 2006 Feb 16;354(7):709-18
pubmed: 16481638
Antibodies (Basel). 2020 Jul 20;9(3):
pubmed: 32698317
J Immunol. 2010 Jun 15;184(12):6719-30
pubmed: 20483725
Nature. 1975 Aug 7;256(5517):495-7
pubmed: 1172191
Clin Cancer Res. 2017 Aug 1;23(15):4270-4279
pubmed: 28223273
J Clin Oncol. 2005 Apr 1;23(10):2346-57
pubmed: 15800326
Cytokine Growth Factor Rev. 2006 Oct;17(5):349-66
pubmed: 16911870
Vaccines (Basel). 2020 Nov 26;8(4):
pubmed: 33255895
Sci Rep. 2018 Oct 24;8(1):15732
pubmed: 30356111
Oncoimmunology. 2017 Nov 13;7(2):e1393597
pubmed: 29308327
Science. 2011 Jan 7;331(6013):44-9
pubmed: 21212348
J Immunother Cancer. 2016 Aug 16;4:50
pubmed: 27532025
Mol Biol Rep. 2018 Dec;45(6):2935-2940
pubmed: 30311129
J Clin Oncol. 2015 Jan 1;33(1):74-82
pubmed: 25403209
PLoS One. 2019 Nov 6;14(11):e0224309
pubmed: 31693710
Proc Natl Acad Sci U S A. 2010 Jun 29;107(26):11906-11
pubmed: 20547866
Anal Cell Pathol (Amst). 2018 Jun 26;2018:5917470
pubmed: 30046513
Nat Rev Cancer. 2003 Sep;3(9):666-75
pubmed: 12951585
Hum Vaccin Immunother. 2017 Nov 2;13(11):2561-2574
pubmed: 28857666
Tumour Biol. 2015 Jun;36(6):4075-8
pubmed: 25934338
Nat Rev Drug Discov. 2003 Sep;2(9):736-46
pubmed: 12951580
Front Immunol. 2021 Mar 30;12:627932
pubmed: 33859638
Oncologist. 2017 Jan;22(1):81-88
pubmed: 27534574
Oncologist. 2006 Apr;11(4):397-408
pubmed: 16614236
Cancer Immunol Res. 2016 Jan;4(1):49-60
pubmed: 26511282
Cancer Immunol Immunother. 2008 Oct;57(10):1569-77
pubmed: 18523771
Clin Transl Immunology. 2014 Jun 20;3(6):e17
pubmed: 25505965
Blood Adv. 2020 Nov 24;4(22):5868-5876
pubmed: 33232480
Front Immunol. 2015 Jul 27;6:368
pubmed: 26284063
Immunology. 2006 Apr;117(4):548-57
pubmed: 16556269
Int J Cancer. 1998 Oct 29;78(3):301-5
pubmed: 9766562
Handb Exp Pharmacol. 2019;260:81-141
pubmed: 31820172
Cancer Chemother Pharmacol. 1987;20(2):137-44
pubmed: 3664933
Nanomedicine. 2019 Jan;15(1):164-174
pubmed: 30291897
Cancer Treat Rev. 2017 Jun;57:36-49
pubmed: 28550712
EBioMedicine. 2019 Nov;49:72-81
pubmed: 31680003
J Thorac Dis. 2018 Dec;10(Suppl 35):S4323-S4334
pubmed: 30701100
Br J Surg. 1996 Apr;83(4):551-5
pubmed: 8665257
Cancer Immunol Res. 2014 Oct;2(10):949-61
pubmed: 25116755
Cancer Immunol Immunother. 2020 Jan;69(1):135-145
pubmed: 31807878
J Viral Hepat. 1997 May;4(3):185-91
pubmed: 9181527
Invest New Drugs. 2020 Feb;38(1):10-19
pubmed: 30887252
Mol Oncol. 2015 Dec;9(10):2043-53
pubmed: 26548534
F1000Res. 2019 May 13;8:
pubmed: 31131086
Cell Chem Biol. 2016 Dec 22;23(12):1515-1525
pubmed: 27889407
Eur J Cancer. 2016 Jun;60:210-25
pubmed: 27084345
J Neurooncol. 2015 Mar;122(1):75-85
pubmed: 25567351
Lancet. 2001 Jun 2;357(9270):1777-89
pubmed: 11403834
Mol Ther. 2017 Apr 5;25(4):976-988
pubmed: 28237837
Cancer Res. 2018 Feb 15;78(4):1031-1043
pubmed: 29222400
Cancer Treat Rev. 2017 Jul;58:70-76
pubmed: 28689073
Gynecol Oncol. 2009 Jan;112(1):192-8
pubmed: 18995891
Cancer Res. 1969 Dec;29(12):2177-83
pubmed: 5369675
Hum Gene Ther. 1993 Aug;4(4):419-31
pubmed: 8399489
J Immunother Cancer. 2020 Apr;8(1):
pubmed: 32317293
Semin Immunol. 2006 Apr;18(2):89-92
pubmed: 16473523
Breast Cancer (Dove Med Press). 2019 Jan 17;11:53-69
pubmed: 30697064
Hepatology. 2011 Jun;53(6):1864-73
pubmed: 21425312
PLoS One. 2017 May 25;12(5):e0178479
pubmed: 28542574
J Exp Med. 1982 Jun 1;155(6):1823-41
pubmed: 6176669
Hum Gene Ther Methods. 2016 Dec;27(6):209-218
pubmed: 27897048
Cancer J. 2015 Nov-Dec;21(6):506-9
pubmed: 26588684
J Immunol. 2014 Oct 15;193(8):4254-60
pubmed: 25217157
Cancer Res. 2013 Jan 1;73(1):139-49
pubmed: 23149919
Gastroenterology. 2019 May;156(7):2056-2072
pubmed: 30660727
Mol Ther. 2017 Sep 06;25(9):1995-1996
pubmed: 28830671
Theranostics. 2018 Nov 10;8(20):5784-5800
pubmed: 30555581
Cell. 2019 May 16;177(5):1172-1186.e14
pubmed: 31031009
J Acquir Immune Defic Syndr (1988). 1989;2(3):217-23
pubmed: 2498507
Oncoimmunology. 2018 Sep 26;7(12):e1502905
pubmed: 30524900
Expert Rev Vaccines. 2016;15(3):313-29
pubmed: 26707950
Ann Acad Med Singap. 2018 Sep;47(9):381-387
pubmed: 30324966
Aging (Albany NY). 2017 Nov 30;9(11):2239-2240
pubmed: 29190214
Clin Cancer Res. 2008 Sep 1;14(17):5610-8
pubmed: 18765555
Hum Vaccin Immunother. 2021 May 4;17(5):1288-1293
pubmed: 33175656
Oncologist. 2012;17(10):1323-8
pubmed: 23002124
JAMA Oncol. 2019 Sep 1;5(9):1310-1317
pubmed: 31169866
Clin Cancer Res. 2018 Apr 1;24(7):1525-1535
pubmed: 29203590
Mol Ther. 2010 Oct;18(10):1874-84
pubmed: 20664527
Cancers (Basel). 2020 Sep 30;12(10):
pubmed: 33008010
Oncotarget. 2016 Aug 2;7(31):49008-49026
pubmed: 27356750
J Hepatol. 2017 Sep;67(3):543-548
pubmed: 28483675
Vaccines (Basel). 2014 Jul 02;2(3):515-36
pubmed: 26344743
N Engl J Med. 2017 Oct 5;377(14):1345-1356
pubmed: 28889792
J Biol Chem. 2006 Jan 20;281(3):1612-9
pubmed: 16284400
Mol Cell Biochem. 2015 Sep;407(1-2):281-7
pubmed: 26048718
Blood. 2018 Jun 7;131(23):2515-2527
pubmed: 29463563
Hematol Oncol Clin North Am. 2001 Aug;15(4):741-73
pubmed: 11676282
J Immunother Cancer. 2019 Apr 8;7(1):100
pubmed: 30961656
Iran J Immunol. 2016 Sep;13(3):148-66
pubmed: 27671507
J Exp Clin Cancer Res. 2017 Nov 7;36(1):156
pubmed: 29115974
J Exp Clin Cancer Res. 2019 Apr 5;38(1):146
pubmed: 30953535
J Immunother Cancer. 2013 Jul 29;1:12
pubmed: 24829749
Ann Transl Med. 2017 Oct;5(19):386
pubmed: 29114544
Adv Cancer Res. 1977;25:323-88
pubmed: 326003
Eur J Cardiothorac Surg. 2016 May;49(5):1324-33
pubmed: 26516195
P T. 2011 Apr;36(4):197-202
pubmed: 21572775
Curr Pharm Biotechnol. 2018;19(1):5-18
pubmed: 29667553
Cancer Res. 2018 Jan 15;78(2):463-474
pubmed: 29187401
Transl Res. 2016 Feb;168:74-95
pubmed: 26297944
Cancer Res. 1989 Dec 1;49(23):6521-8
pubmed: 2819708
Clin Cancer Res. 2008 Sep 15;14(18):5759-68
pubmed: 18794085
Proc Natl Acad Sci U S A. 2009 Oct 13;106(41):17469-74
pubmed: 19805141
Melanoma Res. 2018 Jun;28(3):171-184
pubmed: 29521881
Nat Rev Cancer. 2016 Jan;16(1):7-19
pubmed: 26694935
Mol Oncol. 2021 May;15(5):1358-1375
pubmed: 33338321
Front Oncol. 2018 Sep 27;8:414
pubmed: 30319977
Immunity. 2018 Feb 20;48(2):271-285.e5
pubmed: 29466757
J Immunol Methods. 2014 May;407:63-75
pubmed: 24704820
Chem Rev. 2020 Mar 25;120(6):3210-3229
pubmed: 31804810
Cancer Sci. 2018 Jul;109(7):2130-2140
pubmed: 29790621
J Immunol. 2018 Jan 15;200(2):443-449
pubmed: 29311386
J Exp Med. 1955 Aug 1;102(2):157-77
pubmed: 13242741
Virchows Arch. 2019 Apr;474(4):449-461
pubmed: 30470934
Cancer Immunol Res. 2018 Sep;6(9):1093-1099
pubmed: 29991499
Drug Discov Today. 2020 Mar;25(3):552-560
pubmed: 31843577
J Exp Med. 1973 May 1;137(5):1142-62
pubmed: 4573839
Blood. 2012 May 17;119(20):4656-64
pubmed: 22442347
Clin Cancer Res. 2012 Oct 15;18(20):5752-60
pubmed: 22893631
PLoS One. 2018 Jan 23;13(1):e0191634
pubmed: 29360859
Cell Stem Cell. 2017 Nov 2;21(5):650-664.e8
pubmed: 29100014