Carboxylated-xyloglucan and peptide amphiphile co-assembly in wound healing.
hydrogel
peptide nanofiber
self-assembly
skin tissue engineering
wound healing
Journal
Regenerative biomaterials
ISSN: 2056-3418
Titre abrégé: Regen Biomater
Pays: England
ID NLM: 101652150
Informations de publication
Date de publication:
Oct 2021
Oct 2021
Historique:
received:
16
04
2021
revised:
14
06
2021
accepted:
23
06
2021
entrez:
13
8
2021
pubmed:
14
8
2021
medline:
14
8
2021
Statut:
epublish
Résumé
Hydrogel wound dressings can play critical roles in wound healing protecting the wound from trauma or contamination and providing an ideal environment to support the growth of endogenous cells and promote wound closure. This work presents a self-assembling hydrogel dressing that can assist the wound repair process mimicking the hierarchical structure of skin extracellular matrix. To this aim, the co-assembly behaviour of a carboxylated variant of xyloglucan (CXG) with a peptide amphiphile (PA-H3) has been investigated to generate hierarchical constructs with tuneable molecular composition, structure, and properties. Transmission electron microscopy and circular dichroism at a low concentration shows that CXG and PA-H3 co-assemble into nanofibres by hydrophobic and electrostatic interactions and further aggregate into nanofibre bundles and networks. At a higher concentration, CXG and PA-H3 yield hydrogels that have been characterized for their morphology by scanning electron microscopy and for the mechanical properties by small-amplitude oscillatory shear rheological measurements and compression tests at different CXG/PA-H3 ratios. A preliminary biological evaluation has been carried out both
Identifiants
pubmed: 34386265
doi: 10.1093/rb/rbab040
pii: rbab040
pmc: PMC8355605
doi:
Types de publication
Journal Article
Langues
eng
Pagination
rbab040Subventions
Organisme : Medical Research Council
ID : MR/R015651/1
Pays : United Kingdom
Informations de copyright
© The Author(s) 2021. Published by Oxford University Press.
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