Interleukin-10: A double-edged sword in breast cancer.
Breast cancer
Cytokine
Interleukin-10
Tumor microenvironment
Journal
Tzu chi medical journal
ISSN: 2223-8956
Titre abrégé: Tzu Chi Med J
Pays: India
ID NLM: 101770275
Informations de publication
Date de publication:
Historique:
received:
02
07
2020
revised:
01
08
2020
accepted:
31
08
2020
entrez:
13
8
2021
pubmed:
14
8
2021
medline:
14
8
2021
Statut:
epublish
Résumé
Breast cancer (BC) is a frequently diagnosed cancer among women worldwide. Currently, BC can be divided into different subgroups according to the presence of the following hormone receptors: estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2. Each of these subgroups has different treatment strategies. However, the presence of new metastatic lesions and patient deterioration suggest resistance to a given treatment. Various lines of evidence had shown that cytokines are one of the important mediators of tumor growth, invasion, metastasis, and treatment resistance. Interleukin-10 (IL-10) is an immunoregulatory cytokine, and acts as a poor prognostic marker in many cancers. The anti-inflammatory IL-10 blocks certain effects of inflammatory cytokines. It also antagonizes the co-stimulatory molecules on the antigen-presenting cells. Here, we review the current knowledge on the function and molecular mechanism of IL-10, and recent findings on how IL-10 contributes to the progression of BC.
Identifiants
pubmed: 34386356
doi: 10.4103/tcmj.tcmj_162_20
pii: TCMJ-33-203
pmc: PMC8323643
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
203-211Informations de copyright
Copyright: © 2021 Tzu Chi Medical Journal.
Déclaration de conflit d'intérêts
There are no conflicts of interest.
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