The Immune and Inflammatory Basis of Acquired Pediatric Cardiac Disease.
cardiac remodeling
immune response
inflammation
pediatric heart disease
pediatric vascular disease
Journal
Frontiers in cardiovascular medicine
ISSN: 2297-055X
Titre abrégé: Front Cardiovasc Med
Pays: Switzerland
ID NLM: 101653388
Informations de publication
Date de publication:
2021
2021
Historique:
received:
27
04
2021
accepted:
30
06
2021
entrez:
13
8
2021
pubmed:
14
8
2021
medline:
14
8
2021
Statut:
epublish
Résumé
Children with acquired heart disease face significant health challenges, including a lifetime of strict medical management, multiple cardiac surgeries, and a high mortality risk. Though the presentation of these conditions is diverse, a unifying factor is the role of immune and inflammatory responses in their development and/or progression. For example, infectious agents have been linked to pediatric cardiovascular disease, leading to a large health burden that disproportionately affects low-income areas. Other implicated mechanisms include antibody targeting of cardiac proteins, infection of cardiac cells, and inflammation-mediated damage to cardiac structures. These changes can alter blood flow patterns, change extracellular matrix composition, and induce cardiac remodeling. Therefore, understanding the relationship between the immune system and cardiovascular disease can inform targeted diagnostic and treatment approaches. In this review, we discuss the current understanding of pediatric immune-associated cardiac diseases, challenges in the field, and areas of research with potential for clinical benefit.
Identifiants
pubmed: 34386532
doi: 10.3389/fcvm.2021.701224
pmc: PMC8353076
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
701224Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL140305
Pays : United States
Informations de copyright
Copyright © 2021 Jui, Singampalli, Shani, Ning, Connell, Birla, Bollyky, Caldarone, Keswani and Grande-Allen.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The reviewer EA declared a shared affiliation, with no collaboration, with the authors KLS and YN to the handling editor at the time of the review.
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