Polygenic score modifies risk for Alzheimer's disease in

Alzheimer's disease Alzheimer's disease dementia apolipoprotein E dementia resilience genetic modifiers polygenic risk score

Journal

Alzheimer's & dementia (Amsterdam, Netherlands)
ISSN: 2352-8729
Titre abrégé: Alzheimers Dement (Amst)
Pays: United States
ID NLM: 101654604

Informations de publication

Date de publication:
2021
Historique:
received: 02 05 2021
accepted: 28 06 2021
entrez: 13 8 2021
pubmed: 14 8 2021
medline: 14 8 2021
Statut: epublish

Résumé

Diversity in cognition among apolipoprotein E ( We evaluated a phenotypic extreme polygenic risk score (PRS) for AD between cognitively healthy The PRS for AD was significantly higher in A PRS for AD contributes to modified cognitive expression of the

Identifiants

DOI: 10.1002/dad2.12226 PMID: 34386572 PMC: PMC8339682
pubmed: 34386572
doi: 10.1002/dad2.12226
pii: DAD212226
pmc: PMC8339682
doi:

Types de publication

Journal Article

Langues

eng

Pagination

e12226

Subventions

Organisme : NIA NIH HHS
ID : U24 AG021886
Pays : United States
Organisme : NIH HHS
ID : S10 OD026880
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG058635
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG052411
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG032984
Pays : United States

Informations de copyright

© 2021 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, LLC on behalf of Alzheimer's Association.

Déclaration de conflit d'intérêts

AMG has consulted for Eisai, Biogen, Pfizer, AbbVie, Cognition Therapeutics, and GSK. She also served on the SAB at Denali Therapeutics from 2015–2018. RCS serves as a non‐compensated member of the Board of Directors of the Alzheimer's Association–Illinois Chapter. RCS's institution, Rush University Medical Center, receives research support for his role as a Site Principal Investigator or Site Sub‐Investigator for industry initiated clinical trials and research studies of Alzheimer's disease sponsored by Amylyx Pharmaceuticals, Inc.; Eli Lilly & Co., Inc.; Genentech, Inc.; Lundbeck, Inc.; Merck & Co., Inc.; Navidea Biopharmaceuticals; Novartis Pharmaceuticals, Inc.; Roche Holdings AG; and Takeda Development Center Americas, Inc. All other authors have no interests to declare.

Références

Neurobiol Aging. 2011 Jan;32(1):63-74
pubmed: 19285755
JAMA. 1997 Oct 22-29;278(16):1349-56
pubmed: 9343467
Alzheimers Dement. 2019 Dec;15(12):1612-1623
pubmed: 31506248
Science. 1993 Aug 13;261(5123):921-3
pubmed: 8346443
Age Ageing. 2016 Jul;45(4):511-7
pubmed: 27103599
Genet Epidemiol. 2013 Feb;37(2):142-51
pubmed: 23184518
Lancet. 2020 Aug 8;396(10248):413-446
pubmed: 32738937
Proc Natl Acad Sci U S A. 2019 Feb 5;116(6):2021-2026
pubmed: 30670647
Eur J Hum Genet. 2019 Feb;27(2):244-253
pubmed: 30258121
Genet Med. 2011 Jun;13(6):597-605
pubmed: 21577118
Neurobiol Aging. 2017 Jan;49:214.e7-214.e11
pubmed: 27595457
Nat Genet. 2013 Dec;45(12):1452-8
pubmed: 24162737
Alzheimers Dement. 2006 Apr;2(2):110-7
pubmed: 19595867
N Engl J Med. 1998 Feb 19;338(8):506-11
pubmed: 9468467
Gigascience. 2019 Jul 1;8(7):
pubmed: 31307061
Nat Genet. 2009 Oct;41(10):1088-93
pubmed: 19734902
Bioinformatics. 2015 May 1;31(9):1466-8
pubmed: 25550326
Neurobiol Aging. 2016 May;41:200.e13-200.e20
pubmed: 27036079
J Alzheimers Dis. 2016 Jun 18;53(3):921-32
pubmed: 27340842
Alzheimers Dement. 2014 Nov;10(6):861-8
pubmed: 25217293
J Alzheimers Dis. 2015;43(2):565-73
pubmed: 25096612
Adv Exp Med Biol. 2018;1082:47-122
pubmed: 30357717
Nat Commun. 2020 Sep 23;11(1):4799
pubmed: 32968074
Neurology. 2016 Aug 2;87(5):481-8
pubmed: 27385740
Mol Psychiatry. 2015 Feb;20(2):183-92
pubmed: 25644384
J Neurol Neurosurg Psychiatry. 2015 Dec;86(12):1299-306
pubmed: 26294005
Lancet. 2017 Dec 16;390(10113):2673-2734
pubmed: 28735855
Nat Genet. 1995 Aug;10(4):486-8
pubmed: 7670501
Nat Genet. 2018 Aug;50(8):1112-1121
pubmed: 30038396
Ann Hum Genet. 1999 Jul;63(Pt 4):301-10
pubmed: 10738542
Eur J Hum Genet. 2016 Jun;24(6):919-23
pubmed: 26395552
Hum Mol Genet. 2019 Nov 21;28(R2):R133-R142
pubmed: 31363735
Nat Genet. 2019 Mar;51(3):414-430
pubmed: 30820047
Ann Neurol. 2021 Jan;89(1):54-65
pubmed: 32996171
Nat Genet. 2018 Sep;50(9):1219-1224
pubmed: 30104762
Nat Genet. 2019 Mar;51(3):404-413
pubmed: 30617256
Arch Neurol. 2002 Nov;59(11):1737-46
pubmed: 12433261
Ann N Y Acad Sci. 1996 Dec 16;802:27-34
pubmed: 8993481
PLoS Med. 2017 Mar 21;14(3):e1002258
pubmed: 28323831
Brain. 2015 Dec;138(Pt 12):3673-84
pubmed: 26490334
Lancet Neurol. 2020 Apr;19(4):326-335
pubmed: 31986256
Neurobiol Dis. 2020 Sep;143:104976
pubmed: 32565066
Int Psychogeriatr. 2009 Aug;21(4):672-87
pubmed: 19470201
BMJ. 2017 Dec 6;359:j5375
pubmed: 29212772
Mol Psychiatry. 2017 Jan;22(1):153-160
pubmed: 26976043
J Gerontol A Biol Sci Med Sci. 2017 Oct 12;72(11):1586-1593
pubmed: 28329340
Genet Med. 2020 Oct;22(10):1653-1666
pubmed: 32665703

Auteurs

Aamira J Huq (AJ)

Department of Epidemiology and Preventive Medicine School of Public Health and Preventive Medicine Monash University Melbourne Australia.
Department of Genomic Medicine Royal Melbourne Hospital Melbourne Victoria Australia.
Department of Medicine Royal Melbourne Hospital University of Melbourne Melbourne Victoria Australia.

Brian Fulton-Howard (B)

Nash Family Department of Neuroscience and Ronald Loeb Center for Alzheimer's Disease Icahn School of Medicine at Mount Sinai New York New York USA.
Departments of Neurology and Genetics and Genomic Sciences Icahn School of Medicine at Mount Sinai New York New York USA.

Moeen Riaz (M)

Department of Epidemiology and Preventive Medicine School of Public Health and Preventive Medicine Monash University Melbourne Australia.

Simon Laws (S)

Collaborative Genomics Group Centre of Excellence for Alzheimer's Disease Research and Care School of Medical and Health Sciences Edith Cowan University Joondalup Western Australia Australia.
School of Pharmacy and Biomedical Sciences Faculty of Health Sciences Curtin Health Innovation Perth Western Australia Australia.

Robert Sebra (R)

Departments of Neurology and Genetics and Genomic Sciences Icahn School of Medicine at Mount Sinai New York New York USA.

Joanne Ryan (J)

Department of Epidemiology and Preventive Medicine School of Public Health and Preventive Medicine Monash University Melbourne Australia.

Alan E Renton (AE)

Nash Family Department of Neuroscience and Ronald Loeb Center for Alzheimer's Disease Icahn School of Medicine at Mount Sinai New York New York USA.
Departments of Neurology and Genetics and Genomic Sciences Icahn School of Medicine at Mount Sinai New York New York USA.

Alison M Goate (AM)

Nash Family Department of Neuroscience and Ronald Loeb Center for Alzheimer's Disease Icahn School of Medicine at Mount Sinai New York New York USA.
Departments of Neurology and Genetics and Genomic Sciences Icahn School of Medicine at Mount Sinai New York New York USA.

Colin L Masters (CL)

The Florey Institute University of Melbourne Parkville Victoria Australia.

Elsdon Storey (E)

Department of Epidemiology and Preventive Medicine School of Public Health and Preventive Medicine Monash University Melbourne Australia.

Raj C Shah (RC)

Department of Family Medicine and Rush Alzheimer's Disease Center Rush University Medical Center Chicago Illinois USA.

Anne Murray (A)

Berman Center for Outcomes and Clinical Research Hennepin Healthcare Research Institute Hennepin Healthcare and University of Minnesota Minneapolis Minnesota USA.

John McNeil (J)

Department of Epidemiology and Preventive Medicine School of Public Health and Preventive Medicine Monash University Melbourne Australia.

Ingrid Winship (I)

Department of Genomic Medicine Royal Melbourne Hospital Melbourne Victoria Australia.

Paul A James (PA)

Department of Genomic Medicine Royal Melbourne Hospital Melbourne Victoria Australia.

Paul Lacaze (P)

Department of Epidemiology and Preventive Medicine School of Public Health and Preventive Medicine Monash University Melbourne Australia.

Classifications MeSH