False detection of rifampicin resistance using Xpert
Journal
JAC-antimicrobial resistance
ISSN: 2632-1823
Titre abrégé: JAC Antimicrob Resist
Pays: England
ID NLM: 101765283
Informations de publication
Date de publication:
Sep 2021
Sep 2021
Historique:
received:
15
04
2021
accepted:
22
06
2021
entrez:
13
8
2021
pubmed:
14
8
2021
medline:
14
8
2021
Statut:
epublish
Résumé
In a 12 month period, three Irish-born adult cases with pulmonary TB were initially diagnosed by Xpert Further laboratory investigations on the cultured isolates included GenoType MTBDR Phenotypic drug susceptibility tests determined the isolates to be rifampicin susceptible. Molecular investigations identified an A451V (codon 532) mutation in the False detection of rifampicin resistance, albeit rare, should be considered possible with Xpert
Sections du résumé
BACKGROUND
BACKGROUND
In a 12 month period, three Irish-born adult cases with pulmonary TB were initially diagnosed by Xpert
METHODS
METHODS
Further laboratory investigations on the cultured isolates included GenoType MTBDR
RESULTS
RESULTS
Phenotypic drug susceptibility tests determined the isolates to be rifampicin susceptible. Molecular investigations identified an A451V (codon 532) mutation in the
CONCLUSIONS
CONCLUSIONS
False detection of rifampicin resistance, albeit rare, should be considered possible with Xpert
Identifiants
pubmed: 34386770
doi: 10.1093/jacamr/dlab101
pii: dlab101
pmc: PMC8355037
doi:
Types de publication
Journal Article
Langues
eng
Pagination
dlab101Informations de copyright
© The Author(s) 2021. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy.
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