The haplotype of the
Adult
Aged
Aged, 80 and over
Exfoliation Syndrome
/ diagnosis
Female
Gene Frequency
Genetic Predisposition to Disease
Genotyping Techniques
Glaucoma, Open-Angle
/ diagnosis
Haplotypes
/ genetics
Humans
Intraocular Pressure
/ physiology
Male
Middle Aged
Polymorphism, Single Nucleotide
/ genetics
RNA, Long Noncoding
/ genetics
Russia
/ epidemiology
White People
/ genetics
Association
CDKN2B-AS1 gene
primary open-angle glaucoma
pseudoexfoliation glaucoma
single nucleotide polymorphism
Journal
Ophthalmic genetics
ISSN: 1744-5094
Titre abrégé: Ophthalmic Genet
Pays: England
ID NLM: 9436057
Informations de publication
Date de publication:
12 2021
12 2021
Historique:
pubmed:
14
8
2021
medline:
5
2
2022
entrez:
13
8
2021
Statut:
ppublish
Résumé
To replicate the finding of the association of five A total of 932 participants of Russian ethnicity (self-reported), including 328 patients with PXFG, 208 patients with POAG (high-tension glaucoma), and 396 controls, were enrolled in the study. The SNPs were analyzed for possible associations using logistic regression. Several haplotypes based on the studied SNPs were associated with POAG (three haplotypes) and PXFG (six haplotypes). Haplotype AAAGG of loci rs1063192-rs7865618-rs2157719-rs944800-rs4977756 conferred the highest risk for both POAG (OR = 3.99, р The
Identifiants
pubmed: 34387529
doi: 10.1080/13816810.2021.1955275
doi:
Substances chimiques
CDKN2B antisense RNA, human
0
RNA, Long Noncoding
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM