Specific detection of memory T-cells in COVID-19 patients using standardized whole-blood Interferon gammarelease assay.
Adult
Automation, Laboratory
COVID-19
/ immunology
Cells, Cultured
Cohort Studies
Female
Humans
Interferon-gamma
/ metabolism
Interferon-gamma Release Tests
/ standards
Lymphocyte Activation
Male
Memory T Cells
/ immunology
Middle Aged
SARS-CoV-2
/ physiology
T-Cell Antigen Receptor Specificity
Whole Body Imaging
Young Adult
SARS-CoV-2
T-cells response
immune memory
interferon gamma release assay
Journal
European journal of immunology
ISSN: 1521-4141
Titre abrégé: Eur J Immunol
Pays: Germany
ID NLM: 1273201
Informations de publication
Date de publication:
12 2021
12 2021
Historique:
revised:
30
06
2021
received:
09
04
2021
accepted:
04
08
2021
pubmed:
14
8
2021
medline:
31
12
2021
entrez:
13
8
2021
Statut:
ppublish
Résumé
Antigen-specific T-cells are essential for protective immunity against SARS-CoV-2. We set up a semi-automated whole-blood Interferon-gamma release assay (WB IGRA) to monitor the T-cell response after stimulation with SARS-CoV-2 peptide pools. We report that the WB IGRA is complementary to serological assays to assess SARS-CoV-2 immunity.
Identifiants
pubmed: 34387859
doi: 10.1002/eji.202149296
pmc: PMC8420580
doi:
Substances chimiques
Interferon-gamma
82115-62-6
Types de publication
Letter
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3239-3242Subventions
Organisme : bioMérieux SA
Organisme : Hospices Civils de Lyon
Organisme : Fondation des Hospices Civils de Lyon (HCL)
Organisme : project IDEXLYON
ID : ANR-18-IDEX-0005
Organisme : SFR Biosciences
ID : UAR3444/CNRS
Organisme : SFR Biosciences
ID : US8/Inserm
Informations de copyright
© 2021 The Authors. European Journal of Immunology published by Wiley-VCH GmbH.
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