Association of Perioperative Complications with Vitamin D Levels in Major Head and Neck Surgery.
Vitamin D
calcidiol
fistula
head and neck surgery
Journal
The Laryngoscope
ISSN: 1531-4995
Titre abrégé: Laryngoscope
Pays: United States
ID NLM: 8607378
Informations de publication
Date de publication:
03 2022
03 2022
Historique:
revised:
13
07
2021
received:
30
09
2020
accepted:
14
07
2021
pubmed:
14
8
2021
medline:
11
3
2022
entrez:
13
8
2021
Statut:
ppublish
Résumé
To investigate the association of vitamin D level and perioperative complications in patients undergoing major head and neck surgery. Retrospective Cohort Study. A retrospective chart review was performed for all patients undergoing reconstructive head and neck surgery between December 2017 and December 2019. Data regarding patient demographics, serum 25-hydroxyvitamin D (calcidiol) level, hospital course, prior radiation, and fistula formation were collected. Patients were categorized by serum calcidiol level as deficient (<20 ng/mL) or sufficient (≧20 ng/mL) and outcomes were compared between groups. Fifty-seven patients were included in the analysis. Average age at time of surgery was 62.6 ± 10.6 years. Patients with vitamin D levels <20 ng/mL were considered deficient and ≧20 ng/mL were considered sufficient. Individuals in the deficient group (n = 29) had a mean serum calcidiol level of 13.95 ± 3.95 ng/mL, whereas those in the sufficient group (n = 28) had a mean calcidiol level of 28.53 ± 5.73 ng/mL. The rate of fistula was 41.4% in the deficient group, whereas patients in the sufficient group had a rate of fistula of 14.3% (P = .038). On multivariate analysis, higher serum calcidiol level above 20 ng/mL was associated with a lower likelihood of developing fistulae with an odds ratio 0.830 (95% confidence interval: 0.718-0.960, P = .012). Vitamin D deficiency may play a role in development of fistula after major head and neck surgery. 4 Laryngoscope, 132:578-583, 2022.
Substances chimiques
Vitamin D
1406-16-2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
578-583Informations de copyright
© 2021 The American Laryngological, Rhinological and Otological Society, Inc.
Références
Sayles M, Grant DG. Preventing pharyngo-cutaneous fistula in total laryngectomy: a systematic review and meta-analysis. Laryngoscope 2014;124:1150-1163. https://doi.org/10.1002/lary.24448.
Gombart AF. The vitamin D-antimicrobial peptide pathway and its role in protection against infection. Future Microbiol 2009;4:1151-1165. https://doi.org/10.2217/fmb.09.87.
Schauber J, Gallo RL. The vitamin D pathway: a new target for control of the skin's immune response? Exp Dermatol 2008;17:633-639. https://doi.org/10.1111/j.1600-0625.2008.00768.x.
Gonzalez-Curiel I, Trujillo V, Montoya-Rosales A, et al. 1,25-dihydroxyvitamin D3 induces LL-37 and HBD-2 production in keratinocytes from diabetic foot ulcers promoting wound healing: an in vitro model. PLoS One 2014;9:1-10. https://doi.org/10.1371/journal.pone.0111355.
Gonzalez-Curiel I, Marin-Luevano P, Trujillo V, Enciso-Moreno JA, Gonzalez-Castillo C, Rivas-Santiago B. Calcitriol prevents inflammatory gene expression in macrovascular endothelial cells. Br J Biomed Sci 2016;73:74-78. https://doi.org/10.1080/09674845.2016.1162376.
Oda Y, Tu C-L, Menendez A, Nguyen T, Bikle D. Vitamin D and calcium regulation of epidermal wound healing. J Steroid Biochem Mol Biol 2016;164:379-385. https://doi.org/10.1016/j.physbeh.2017.03.040.
Bikle DD. Vitamin D metabolism, mechanism of action, and clinical applications. Chem Biol 2014;21:319-329. https://doi.org/10.1016/j.chembiol.2013.12.016.
Gorman S, Buckley AG, Ling KM, et al. Vitamin D supplementation of initially vitamin D-deficient mice diminishes lung inflammation with limited effects on pulmonary epithelial integrity. Physiol Rep 2017;5:1-12. https://doi.org/10.14814/phy2.13371.
Razzaghi R, Pourbagheri H, Momen-Heravi M, et al. The effects of vitamin D supplementation on wound healing and metabolic status in patients with diabetic foot ulcer: a randomized, double-blind, placebo-controlled trial. J Diabetes Complications 2017;31:766-772. https://doi.org/10.1016/j.jdiacomp.2016.06.017.
Anand A, Singh S, Sonkar AA, et al. Expression of vitamin D receptor and vitamin D status in patients with oral neoplasms and effect of vitamin D supplementation on quality of life in advanced cancer treatment. Wspolczesna Onkol 2017;21:145-151. https://doi.org/10.5114/wo.2017.68623.
Bakr IS, Zaki AM, El-Moslemany RM, Elsaka RO. Vitamin D oral gel for prevention of radiation-induced oral mucositis: a randomized clinical trial. Oral Dis 2020;27:1-8. https://doi.org/10.1111/odi.13650.
Pludowski P, Holick MF, Grant WB, et al. Vitamin D supplementation guidelines. J Steroid Biochem Mol Biol 2018;175:125-135. https://doi.org/10.1016/j.jsbmb.2017.01.021.
Teknos TN, Myers LL. Surgical reconstruction after chemotherapy or radiation: problems and solutions. Hematol Oncol Clin North Am 1999;13:679-687. https://doi.org/10.1016/S0889-8588(05)70085-X.
Sirajudeen S, Shah I, Al MA. A narrative role of vitamin d and its receptor: with current evidence on the gastric tissues. Int J Mol Sci 2019;20:3832. https://doi.org/10.3390/ijms20153832.
Oda Y, Tu C-L, Menendez A, Nguyen T, Bikle D. Vitamin D and calcium regulation of epidermal wound. J Steroid Biochem Mol Biol 2016;164:379-385. https://doi.org/10.1016/j.physbeh.2017.03.040.
Li YC, Chen Y, Du J. Critical roles of intestinal epithelial vitamin D receptor signaling in controlling gut mucosal inflammation. J Steroid Biochem Mol Biol 2015;148:179-183. https://doi.org/10.1016/j.jsbmb.2015.01.011.
Lau FH, Majumder R, Torabi R, et al. Vitamin D insufficiency is prevalent in severe COVID-19. 2020. https://doi.org/10.1101/2020.04.24.20075838.
Raharusuna P, Priambada S, Budiarti C, et al. Patterns of COVID-19 mortality and vitamin D: an Indonesian study; 2020. Available at: https://ssrn.com/abstract=3585561. Accessed May 20, 2020.
Daneshkhah A, Eshein A, Subramanian H, Roy HK, Backman V. The role of vitamin D in suppressing cytokine storm in COVID-19 patients and associated mortality. Aging Clin Exp Res. 2020;32:2141-2158. https://doi.org/10.1101/2020.04.08.20058578.
Wimalawansa SJ. Non-musculoskeletal benefits of vitamin D. J Steroid Biochem Mol Biol 2018;175:60-81. https://doi.org/10.1016/j.jsbmb.2016.09.016.