Roles of physical exercise in neurodegeneration: reversal of epigenetic clock.
DNA methylation
Motor deficits
Neural mechanism
Neurodegeneration
Physical exercise
Journal
Translational neurodegeneration
ISSN: 2047-9158
Titre abrégé: Transl Neurodegener
Pays: England
ID NLM: 101591861
Informations de publication
Date de publication:
13 08 2021
13 08 2021
Historique:
received:
01
05
2021
accepted:
29
07
2021
entrez:
14
8
2021
pubmed:
15
8
2021
medline:
29
1
2022
Statut:
epublish
Résumé
The epigenetic clock is defined by the DNA methylation (DNAm) level and has been extensively applied to distinguish biological age from chronological age. Aging-related neurodegeneration is associated with epigenetic alteration, which determines the status of diseases. In recent years, extensive research has shown that physical exercise (PE) can affect the DNAm level, implying a reversal of the epigenetic clock in neurodegeneration. PE also regulates brain plasticity, neuroinflammation, and molecular signaling cascades associated with epigenetics. This review summarizes the effects of PE on neurodegenerative diseases via both general and disease-specific DNAm mechanisms, and discusses epigenetic modifications that alleviate the pathological symptoms of these diseases. This may lead to probing of the underpinnings of neurodegenerative disorders and provide valuable therapeutic references for cognitive and motor dysfunction.
Identifiants
pubmed: 34389067
doi: 10.1186/s40035-021-00254-1
pii: 10.1186/s40035-021-00254-1
pmc: PMC8361623
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
30Informations de copyright
© 2021. The Author(s).
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