Changes of discharge properties of neurons from dorsomedial hypothalamic nuclei during aging in rats.
Aging
Extracellular recording
Firing activity
Hypothalamus
Journal
Neuroscience letters
ISSN: 1872-7972
Titre abrégé: Neurosci Lett
Pays: Ireland
ID NLM: 7600130
Informations de publication
Date de publication:
25 09 2021
25 09 2021
Historique:
received:
04
06
2021
revised:
28
07
2021
accepted:
05
08
2021
pubmed:
15
8
2021
medline:
21
1
2022
entrez:
14
8
2021
Statut:
ppublish
Résumé
The hypothalamus is a vital brain center that is participated in the integration of the endocrine and nervous systems and control of the homeostasis and aging. Spontaneous firing activity from single neurons of the dorsomedial hypothalamic nucleus (DMN) was studied extracellularly in vivo in urethane-anaesthetized rats. The discharge patterns of the majority of DMN neurons were irregular, including periods of relatively stable activity interrupted by pauses. Based on the features of interval interspike histogram, we have selected neurons with an irregular arrhythmic activity (50% in young, 46% in adult and 44% in aged rats), with a constant rhythmic activity (18% of neurons in young, 19% in adult and 23% in aged rats), with a wide interspike interval distribution (22% in young, 26% in adult and 25% in aged rats) and cells with bursts of two or three spikes (10% in young, 9% in adult and 8% in aged rats). The firing rate of DMN neurons was 2.5 ± 0.12 Hz in young and 2.4 ± 0.21 Hz in adult rats and significantly decreased to 1.8 ± 0.17 Hz in aged rats.
Identifiants
pubmed: 34389479
pii: S0304-3940(21)00546-2
doi: 10.1016/j.neulet.2021.136168
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
136168Informations de copyright
Copyright © 2021 Elsevier B.V. All rights reserved.