Safety of procuring research tissue during a clinically indicated kidney biopsy from patients with lupus: data from the Accelerating Medicines Partnership RA/SLE Network.
autoimmunity
lupus erythematosus
lupus nephritis
systemic
Journal
Lupus science & medicine
ISSN: 2053-8790
Titre abrégé: Lupus Sci Med
Pays: England
ID NLM: 101633705
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
received:
19
05
2021
accepted:
28
07
2021
entrez:
14
8
2021
pubmed:
15
8
2021
medline:
16
10
2021
Statut:
ppublish
Résumé
In lupus nephritis the pathological diagnosis from tissue retrieved during kidney biopsy drives treatment and management. Despite recent approval of new drugs, complete remission rates remain well under aspirational levels, necessitating identification of new therapeutic targets by greater dissection of the pathways to tissue inflammation and injury. This study assessed the safety of kidney biopsies in patients with SLE enrolled in the Accelerating Medicines Partnership, a consortium formed to molecularly deconstruct nephritis. 475 patients with SLE across 15 clinical sites in the USA consented to obtain tissue for research purposes during a clinically indicated kidney biopsy. Adverse events (AEs) were documented for 30 days following the procedure and were determined to be related or unrelated by all site investigators. Serious AEs were defined according to the National Institutes of Health reporting guidelines. 34 patients (7.2%) experienced a procedure-related AE: 30 with haematoma, 2 with jets, 1 with pain and 1 with an arteriovenous fistula. Eighteen (3.8%) experienced a serious AE requiring hospitalisation; four patients (0.8%) required a blood transfusion related to the kidney biopsy. At one site where the number of cores retrieved during the biopsy was recorded, the mean was 3.4 for those who experienced a related AE (n=9) and 3.07 for those who did not experience any AE (n=140). All related AEs resolved. Procurement of research tissue should be considered feasible, accompanied by a complication risk likely no greater than that incurred for standard clinical purposes. In the quest for targeted treatments personalised based on molecular findings, enhanced diagnostics beyond histology will likely be required.
Identifiants
pubmed: 34389634
pii: 8/1/e000522
doi: 10.1136/lupus-2021-000522
pmc: PMC8354250
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIAMS NIH HHS
ID : UH2 AR067685
Pays : United States
Organisme : NIAMS NIH HHS
ID : UM2 AR067678
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR003167
Pays : United States
Organisme : NHGRI NIH HHS
ID : T32 HG002295
Pays : United States
Organisme : NIAMS NIH HHS
ID : UH2 AR067681
Pays : United States
Organisme : NIAMS NIH HHS
ID : UH2 AR067688
Pays : United States
Organisme : NIAMS NIH HHS
ID : UH2 AR067689
Pays : United States
Organisme : NIAMS NIH HHS
ID : UH2 AR067690
Pays : United States
Organisme : NIAMS NIH HHS
ID : UH2 AR067677
Pays : United States
Organisme : NIAMS NIH HHS
ID : UH2 AR067694
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR075423
Pays : United States
Organisme : NIAMS NIH HHS
ID : UH2 AR067679
Pays : United States
Organisme : NIAMS NIH HHS
ID : UH2 AR067676
Pays : United States
Organisme : NIAMS NIH HHS
ID : UH2 AR067691
Pays : United States
Investigateurs
Jennifer Goff
(J)
Patrick Dunn
(P)
Soumya Raychaudhuri
(S)
Fan Zhang
(F)
Ilya Korsunsky
(I)
Aparna Nathan
(A)
Joseph Mears
(J)
Kazuyoshi Ishigaki
(K)
Qian Xiao
(Q)
Nghia Millard
(N)
Kathryn Weinand
(K)
Saori Sakaue
(S)
P J Utz
(PJ)
Rong Mao
(R)
Bill Robinson
(B)
Holden Maecker
(H)
Joel Guthridge
(J)
Wade DeJager
(W)
Susan Macwana
(S)
Louis Bridges
(L)
Vivian Bykerk
(V)
Laura Donlin
(L)
Susan Goodman
(S)
Edward DiCarlo
(E)
Melanie Smith
(M)
Amit Lakhanpal
(A)
Heather Sherman
(H)
Anvita Singaraju
(A)
Lorien Shakib
(L)
Christopher Ritchlin
(C)
Brendan Boyce
(B)
Darren Tabechian
(D)
Andrew McDavid
(A)
Javier Rangel-Moreno
(J)
Nida Meednu
(N)
Jen Albrecht
(J)
Michael Brenner
(M)
James Lederer
(J)
Kevin Wei
(K)
A Helena Jonsson
(AH)
Daimon Simmons
(D)
Gregory Keras
(G)
Joshua Keegan
(J)
Gerald Watts
(G)
Yuhong Li
(Y)
Zhu Zhu
(Z)
Adam Chicoine
(A)
Zhihan Jian Li
(ZJ)
Mandy McGeachy
(M)
Gary Firestein
(G)
David Boyle
(D)
Arnold Ceponis
(A)
Peter Gregersen
(P)
Diane Horowitz
(D)
Harris Perlman
(H)
Salina Dominguez
(S)
Carla Cuda
(C)
Arthur Mandelin
(A)
Anjali Thakrar
(A)
Joan Bathon
(J)
Laura Hughes
(L)
Mike Holers
(M)
Jennifer Seifert
(J)
Kevin Deane
(K)
Larry Moreland
(L)
Andrew Filer
(A)
Karim Raza
(K)
Ilfita Sahbudin
(I)
Constanino Pitzalis
(C)
Myles Lewis
(M)
Felice Rivellese
(F)
Alessandra Nerviani
(A)
Michele Bombardieri
(M)
Lindsy Forbess
(L)
Ami Ben-Artzi
(A)
Karen Salomon-Escoto
(K)
Ellen Gravallese
(E)
Jennifer Barnas
(J)
Arnon Arazi
(A)
Raymond Hsu
(R)
Robert Clancy
(R)
Beatrice Goilav
(B)
Steven Woodle
(S)
David Hildeman
(D)
Nir Hacohen
(N)
Paul Hoover
(P)
Thomas Eisenhaure
(T)
Michael Peters
(M)
Tony Jones
(T)
David Lieb
(D)
Thomas Tuschl
(T)
Hemant Suryawanshi
(H)
Manjunath Kustagi
(M)
Maureen McMahon
(M)
Jennifer Grossman
(J)
Matthias Kretzler
(M)
Jeffrey Hodgin
(J)
Raji Menon
(R)
Pavel Morozov
(P)
Informations de copyright
© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
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