A direct interareal feedback-to-feedforward circuit in primate visual cortex.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
13 08 2021
13 08 2021
Historique:
received:
28
07
2020
accepted:
08
07
2021
entrez:
14
8
2021
pubmed:
15
8
2021
medline:
31
8
2021
Statut:
epublish
Résumé
The mammalian sensory neocortex consists of hierarchically organized areas reciprocally connected via feedforward (FF) and feedback (FB) circuits. Several theories of hierarchical computation ascribe the bulk of the computational work of the cortex to looped FF-FB circuits between pairs of cortical areas. However, whether such corticocortical loops exist remains unclear. In higher mammals, individual FF-projection neurons send afferents almost exclusively to a single higher-level area. However, it is unclear whether FB-projection neurons show similar area-specificity, and whether they influence FF-projection neurons directly or indirectly. Using viral-mediated monosynaptic circuit tracing in macaque primary visual cortex (V1), we show that V1 neurons sending FF projections to area V2 receive monosynaptic FB inputs from V2, but not other V1-projecting areas. We also find monosynaptic FB-to-FB neuron contacts as a second motif of FB connectivity. Our results support the existence of FF-FB loops in primate cortex, and suggest that FB can rapidly and selectively influence the activity of incoming FF signals.
Identifiants
pubmed: 34389710
doi: 10.1038/s41467-021-24928-6
pii: 10.1038/s41467-021-24928-6
pmc: PMC8363744
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
4911Subventions
Organisme : NEI NIH HHS
ID : R01 EY019743
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY031959
Pays : United States
Organisme : NINDS NIH HHS
ID : U01 NS099702
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY026812
Pays : United States
Organisme : NEI NIH HHS
ID : P30 EY014800
Pays : United States
Informations de copyright
© 2021. The Author(s).
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