The determinants of lipid profiles in early adolescence in a Ugandan birth cohort.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
13 08 2021
13 08 2021
Historique:
received:
31
07
2020
accepted:
02
08
2021
entrez:
14
8
2021
pubmed:
15
8
2021
medline:
12
11
2021
Statut:
epublish
Résumé
Dyslipidaemia in adolescence tracks into adulthood and is an important risk factor for cardiovascular disease. Little is known about the effects of environmental exposures and early-life exposure to infectious diseases common to tropical regions on lipids. In 1119 early adolescent participants in the Entebbe Mother and Baby Study, we used linear regression to examine whether prenatal, childhood or adolescent factors are associated with lipid levels. Reduced high-density lipoprotein (HDL) and elevated triglyceride levels were common (prevalence 31% and 14%, respectively), but elevated low-density lipoprotein (LDL) or total cholesterol (TC) were rare. Current malaria infection was associated with lower mean LDL (adjusted ß - 0.51; 95% CI - 0.81, - 0.21), HDL (adjusted ß - 0.40; 95% CI - 0.56, - 0.23), and TC levels (adjusted ß - 0.62; 95% CI - 0.97, - 0.27), but higher mean triglyceride levels (geometric mean ratio (GMR) 1.47; 95% CI 1.18-1.84). Early-life asymptomatic malaria was associated with modest reductions in HDL and TC. Body mass index (BMI) was positively associated with LDL, TC, and triglycerides. No associations with helminth infection were found. Our findings suggest that early-life factors have only marginal effects on the lipid profile. Current malaria infection and BMI are strongly associated with lipids and important to consider when trying to improve the lipid profile.
Identifiants
pubmed: 34389769
doi: 10.1038/s41598-021-96035-x
pii: 10.1038/s41598-021-96035-x
pmc: PMC8363641
doi:
Substances chimiques
Cholesterol, LDL
0
Lipids
0
Lipoproteins, HDL
0
Triglycerides
0
Cholesterol
97C5T2UQ7J
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
16503Subventions
Organisme : Wellcome Trust
ID : 064693
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00027/5
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/K012126/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/R010161/1
Pays : United Kingdom
Informations de copyright
© 2021. The Author(s).
Références
Circulation. 2018 Mar 20;137(12):1246-1255
pubmed: 29170152
Int J Sports Med. 2002 May;23 Suppl 1:S39-43
pubmed: 12012261
Clin Nutr. 2005 Feb;24(1):16-31
pubmed: 15681098
Lancet. 2011 Jan 1;377(9759):52-62
pubmed: 21176950
Ann Hum Biol. 2013 Mar;40(2):168-74
pubmed: 23327188
Circulation. 2019 Jun 18;139(25):e1046-e1081
pubmed: 30565953
Lipids Health Dis. 2005 May 09;4:10
pubmed: 15882457
Arterioscler Thromb Vasc Biol. 1997 Jan;17(1):95-106
pubmed: 9012643
MMWR Morb Mortal Wkly Rep. 2010 Jan 22;59(2):29-33
pubmed: 20094024
Lancet Glob Health. 2018 Sep;6(9):e998-e1007
pubmed: 30103999
Clin Infect Dis. 2020 Jul 27;71(3):601-613
pubmed: 31504336
J Hum Hypertens. 2019 Sep;33(9):679-692
pubmed: 30804461
Int J Epidemiol. 2019 Feb 1;48(1):148-156
pubmed: 29982658
BMC Public Health. 2018 Mar 6;18(1):320
pubmed: 29510714
Circulation. 2017 Mar 7;135(10):e146-e603
pubmed: 28122885
Malar J. 2013 Dec 07;12:442
pubmed: 24314058
Am J Clin Nutr. 2011 Sep;94(3):877-83
pubmed: 21775565
Circulation. 2013 Jul 2;128(1):72-8
pubmed: 23817482
Mol Genet Genomic Med. 2019 Oct;7(10):e00950
pubmed: 31469255
Atherosclerosis. 2013 Jun;228(2):306-15
pubmed: 23518178
Science. 2002 Apr 19;296(5567):490-4
pubmed: 11964470
Arch Intern Med. 1999 May 24;159(10):1049-57
pubmed: 10335681
Ann Pediatr Endocrinol Metab. 2013 Mar;18(1):1-8
pubmed: 24904843
J Infect Dis. 2000 Jun;181 Suppl 3:S462-72
pubmed: 10839741
Pediatrics. 1994 Jun;93(6 Pt 1):977-85
pubmed: 8190587
JAMA Pediatr. 2015 Mar;169(3):272-9
pubmed: 25599372
N Engl J Med. 2012 Jan 26;366(4):321-9
pubmed: 22276822
J Nutr. 2015 Oct;145(10):2389-95
pubmed: 26338888
Clin Trials. 2007;4(1):42-57
pubmed: 17327245
Arq Bras Cardiol. 2009 Jun;92(6):412-7, 429-34, 446-51
pubmed: 19629307
Front Immunol. 2019 Oct 15;10:2398
pubmed: 31681289
Clin Infect Dis. 2010 Feb 15;50(4):531-40
pubmed: 20067426
Am J Clin Nutr. 2014 Jul;100(1):46-52
pubmed: 24717340
Pediatrics. 2019 May;143(5):
pubmed: 30967484
Prim Care. 2013 Mar;40(1):195-211
pubmed: 23402469
Trans R Soc Trop Med Hyg. 2007 Sep;101(9):899-907
pubmed: 17555783
PLoS One. 2013;8(1):e54855
pubmed: 23365679
Circulation. 2014 Jun 24;129(25 Suppl 2):S1-45
pubmed: 24222016
Int J Epidemiol. 2003 Oct;32(5):862-76
pubmed: 14559765
Vaccine. 2017 Dec 4;35(48 Pt A):6492-6500
pubmed: 29150054
Trends Parasitol. 2014 Apr;30(4):183-90
pubmed: 24642035
PLoS Negl Trop Dis. 2017 Oct 4;11(10):e0005953
pubmed: 28976979
J Clin Lipidol. 2015 May-Jun;9(3):334-42
pubmed: 26073391
Ann Intern Med. 2017 Dec 5;167(11):ITC81-ITC96
pubmed: 29204622
Circulation. 2006 Feb 14;113(6):898-918
pubmed: 16380542
Am J Epidemiol. 1991 May 1;133(9):884-99
pubmed: 2028978