Investigation of gene-environment interactions in relation to tic severity.

Attention Deficit Disorder with Hyperactivity / genetics Autism Spectrum Disorder / genetics Female Gene-Environment Interaction Genome-Wide Association Study Humans Pregnancy Severity of Illness Index Tics Tourette Syndrome
Gene–environment interaction Pre- and perinatal complications Tic severity Tourette syndrome

Journal

Journal of neural transmission (Vienna, Austria : 1996)
ISSN: 1435-1463
Titre abrégé: J Neural Transm (Vienna)
Pays: Austria
ID NLM: 9702341

Informations de publication

Date de publication:
11 2021
Historique:
received: 21 05 2021
accepted: 28 07 2021
pubmed: 15 8 2021
medline: 30 10 2021
entrez: 14 8 2021
Statut: ppublish

Résumé

Tourette syndrome (TS) is a neuropsychiatric disorder with involvement of genetic and environmental factors. We investigated genetic loci previously implicated in Tourette syndrome and associated disorders in interaction with pre- and perinatal adversity in relation to tic severity using a case-only (N = 518) design. We assessed 98 single-nucleotide polymorphisms (SNPs) selected from (I) top SNPs from genome-wide association studies (GWASs) of TS; (II) top SNPs from GWASs of obsessive-compulsive disorder (OCD), attention-deficit/hyperactivity disorder (ADHD), and autism spectrum disorder (ASD); (III) SNPs previously implicated in candidate-gene studies of TS; (IV) SNPs previously implicated in OCD or ASD; and (V) tagging SNPs in neurotransmitter-related candidate genes. Linear regression models were used to examine the main effects of the SNPs on tic severity, and the interaction effect of these SNPs with a cumulative pre- and perinatal adversity score. Replication was sought for SNPs that met the threshold of significance (after correcting for multiple testing) in a replication sample (N = 678). One SNP (rs7123010), previously implicated in a TS meta-analysis, was significantly related to higher tic severity. We found a gene-environment interaction for rs6539267, another top TS GWAS SNP. These findings were not independently replicated. Our study highlights the future potential of TS GWAS top hits in gene-environment studies.

Identifiants

DOI: 10.1007/s00702-021-02396-y PMID: 34389898 PMC: PMC8536549
pubmed: 34389898
doi: 10.1007/s00702-021-02396-y
pii: 10.1007/s00702-021-02396-y
pmc: PMC8536549
mid: NIHMS1750187
doi:

Types de publication

Journal Article Meta-Analysis Research Support, Non-U.S. Gov't Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

1757-1765

Subventions

Organisme : NIMH NIH HHS
ID : R01 MH092292
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH092513
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH071507
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH079488
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH092520
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH092290
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH079494
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS040024
Pays : United States
Organisme : NIMH NIH HHS
ID : U24 MH068457
Pays : United States
Organisme : NIMH NIH HHS
ID : R13 MH073250
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH079487
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH092516
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH092291
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES021462
Pays : United States
Organisme : NINDS NIH HHS
ID : U01 NS040024
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH115958
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS016648
Pays : United States
Organisme : NIMH NIH HHS
ID : K08 MH099424
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH092289
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH079489
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH115963
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH092293
Pays : United States

Informations de copyright

© 2021. The Author(s).

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Auteurs

Mohamed Abdulkadir (M)

Department of Child and Adolescent Psychiatry, University Medical Center Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands. mohamedabdulkadir@gmail.com.
Department of Genetics and the Human Genetics Institute of New Jersey, Rutgers, The State University of New Jersey, Piscataway, NJ, 08854, USA. mohamedabdulkadir@gmail.com.
ORCID: 0000-0002-6080-257X

Dongmei Yu (D)

Department of Neurology, Center for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.
Department of Psychiatry, Psychiatric and Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.

Lisa Osiecki (L)

Department of Psychiatry, Psychiatric and Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.

Robert A King (RA)

Yale Child Study Center, Yale University School of Medicine, New Haven, CT, 06510, USA.

Thomas V Fernandez (TV)

Yale Child Study Center, Yale University School of Medicine, New Haven, CT, 06510, USA.

Lawrence W Brown (LW)

Pediatric Neuropsychiatry Program, Division of Neurology, The Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.

Keun-Ah Cheon (KA)

Yonsei University College of Medicine, Severance Hospital, Seoul, 120-752, South Korea.

Barbara J Coffey (BJ)

Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY, USA.
University of Miami Miller School of Medicine, Miami, FL, 33146, USA.

Blanca Garcia-Delgar (B)

Department of Child and Adolescent Psychiatry and Psychology, Institute of Neurosciences, Hospital Clinic Universitari, Barcelona, Spain.

Donald L Gilbert (DL)

Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.

Dorothy E Grice (DE)

Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Julie Hagstrøm (J)

Child and Adolescent Mental Health Center, Mental Health Services, Capital Region of Denmark and Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.

Tammy Hedderly (T)

Evelina London Children's Hospital GSTT, Kings Health Partners AHSC, London, UK.

Isobel Heyman (I)

Psychological Medicine, UCL Great Ormond Street Institute of Child Health, London, UK.

Hyun Ju Hong (HJ)

Department of Psychiatry, Hallym University Sacred Heart Hospital, Anyang, Gyeonggi, 14068, South Korea.

Chaim Huyser (C)

Academic Center for Child and Adolescent Psychiatry De Bascule, 1105 AZ, Amsterdam, The Netherlands.

Laura Ibanez-Gomez (L)

Family Health Centers at NYU Langone, Brooklyn, NY, 11220, USA.

Young Key Kim (YK)

Department of Psychiatry, Yonsei Bom Clinic, Seoul, 03330, South Korea.

Young-Shin Kim (YS)

University of California San Francisco Medical Center, San Francisco, CA, 94143, USA.

Yun-Joo Koh (YJ)

Korea Institute for Children's Social Development, Seoul, South Korea.

Sodahm Kook (S)

Yonsei-Nuri Mental Health Clinic, Seoul, 08005, South Korea.

Samuel Kuperman (S)

Department of Psychiatry, Carver College of Medicine, University of Iowa, Iowa, IA, 52242, USA.

Bennett Leventhal (B)

University of California San Francisco Medical Center, San Francisco, CA, 94143, USA.

Marcos Madruga-Garrido (M)

Sección de Neuropediatría, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain.

Athanasios Maras (A)

Yulius Academy, Yulius Mental Health Organization, 3311 JG, Dordrecht, The Netherlands.

Pablo Mir (P)

Unidad de Trastornos del MovimientoInstituto de Biomedicina de Sevilla (IBiS). Hospital Universitario Virgen del Rocío/CSICUniversidad de Sevilla, Seville, Spain.

Astrid Morer (A)

Department of Child and Adolescent Psychiatry and Psychology, Institute of Neurosciences, Hospital Clinic Universitari Barcelona, Spain; Institut d'Investigacions Biomediques August Pi i Sunyer (IDIPABS) and Centro de Investigacion en Red de Salud Mental (CIBERSAM), Barcelona, Spain.

Alexander Münchau (A)

Institute of Systems of Motor Science, University of Lübeck, 23562, Lübeck, Germany.

Kerstin J Plessen (KJ)

Child and Adolescent Mental Health Center, Mental Health Services, Capital Region of Denmark and Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.

Veit Roessner (V)

Department of Child and Adolescent Psychiatry, TU Dresden, Dresden, Germany.

Eun-Young Shin (EY)

Yonsei University College of Medicine, Severance Hospital, Seoul, 120-752, South Korea.

Dong-Ho Song (DH)

Yonsei University Severance Hospital, Seoul, 03722, South Korea.

Jungeun Song (J)

Department of Psychiatry, National Health Insurance Service Ilsan Hospital, Goyang, Gyeonggi, 10444, South Korea.

Frank Visscher (F)

Admiraal De Ruyter Ziekenhuis, Department of Neurology, Goes, The Netherlands.

Samuel H Zinner (SH)

Department of Pediatrics, Division of Developmental Medicine, University of Washington School of Medicine, 1925 NE Pacific Street, Box 356524, Seattle, WA, 98195, USA.

Carol A Mathews (CA)

Department of Psychiatry, Center for OCD, Anxiety and Related Disorders, and Genetics Institute, University of Florida College of Medicine, Gainesville, FL, 32611, USA.

Jeremiah M Scharf (JM)

Department of Neurology, Center for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.
Department of Psychiatry, Psychiatric and Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.

Jay A Tischfield (JA)

Department of Genetics and the Human Genetics Institute of New Jersey, Rutgers, The State University of New Jersey, Piscataway, NJ, 08854, USA.

Gary A Heiman (GA)

Department of Genetics and the Human Genetics Institute of New Jersey, Rutgers, The State University of New Jersey, Piscataway, NJ, 08854, USA.

Andrea Dietrich (A)

Department of Child and Adolescent Psychiatry, University Medical Center Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands.

Pieter J Hoekstra (PJ)

Department of Child and Adolescent Psychiatry, University Medical Center Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands.

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Classifications MeSH

questionsmedicales.fr › Troubles mentaux › Troubles du développement neurologique › Troubles déficitaires de l'attention et du comportement perturbateur › Trouble déficitaire de l'attention avec hyperactivité › Investigation of gene-environment interactions...
questionsmedicales.fr › Troubles mentaux › Troubles du développement neurologique › Troubles généralisés du développement de l'enfant › Trouble du spectre autistique › Investigation of gene-environment interactions...
questionsmedicales.fr › Phénomènes génétiques › Phénotype › Interaction entre gènes et environnement › Investigation of gene-environment interactions...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Épidémiologie moléculaire › Étude d'association pangénomique › Investigation of gene-environment interactions...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Investigation of gene-environment interactions...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Grossesse › Investigation of gene-environment interactions...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Collecte de données › Enquêtes et questionnaires › Enquêtes de santé › Indicateurs d'état de santé › Acuité des besoins du patient › Indice de gravité de la maladie › Investigation of gene-environment interactions...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Manifestations neurologiques › Dyskinésies › Tics › Investigation of gene-environment interactions...
questionsmedicales.fr › Troubles mentaux › Troubles du développement neurologique › Troubles des tics › Syndrome de Tourette › Investigation of gene-environment interactions...