Mushrooms on the plate: Trends towards NAFLD treatment, health improvement and sustainable diets.
NAFLD treatment
gut-liver axis protection
liver-adipose tissue axis
mushrooms
non-communicable diseases
sustainable healthy diets
Journal
European journal of clinical investigation
ISSN: 1365-2362
Titre abrégé: Eur J Clin Invest
Pays: England
ID NLM: 0245331
Informations de publication
Date de publication:
Mar 2022
Mar 2022
Historique:
revised:
06
07
2021
received:
07
05
2021
accepted:
08
07
2021
pubmed:
15
8
2021
medline:
18
3
2022
entrez:
14
8
2021
Statut:
ppublish
Résumé
Non-alcoholic fatty liver disease (NAFLD) is a most important cause of liver disease. Similar to other non-communicable diseases (NCD), such as obesity and type II diabetes mellitus, NAFLD can strongly affected by diet. Diet-related NCD and malnutrition are rising in all regions being a major cause of the global health, economic and environmental burdens. Mushrooms, important dietary components since the hunter-gathering communities, have increasingly gained momentum in biomedical research and therapeutics due to their interplay in metabolism traits. We emphasize here the beneficial effects of mushroom-enriched diets on the homeostasis of lipid and sugar metabolism, including their modulation, but also interfering with insulin metabolism, gut microbiota, inflammation, oxidative stress and autophagy. In this review, we describe the cellular and molecular mechanisms at the gut-liver axis and the liver-white adipose tissue (WAT) axis, that plausibly cause such positive modulation, and discuss the potential of mushroom-enriched diets to prevent or ameliorate NAFLD and related NCD, also within the shift needed towards healthy sustainable diets.
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e13667Subventions
Organisme : H2020 Marie Skłodowska-Curie Actions
ID : ID: 722619, ID: 734719
Organisme : FOIE GRAS and mtFOIE GRAS projects
Informations de copyright
© 2021 Stichting European Society for Clinical Investigation Journal Foundation. Published by John Wiley & Sons Ltd.
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