Current tools to interrogate microglial biology.
Journal
Neuron
ISSN: 1097-4199
Titre abrégé: Neuron
Pays: United States
ID NLM: 8809320
Informations de publication
Date de publication:
15 09 2021
15 09 2021
Historique:
received:
02
05
2021
revised:
23
06
2021
accepted:
06
07
2021
pubmed:
15
8
2021
medline:
6
10
2021
entrez:
14
8
2021
Statut:
ppublish
Résumé
Microglial cells perform a plethora of functions in the central nervous system (CNS), involving them in brain development, maintenance of homeostasis in adulthood, and CNS diseases. Significant technical advancements have prompted the development of novel systems adapted to analyze microglia with increasing specificity and intricacy. The advent of single-cell technologies combined with targeted mouse models has been decisive in deciphering microglia heterogeneity and dissecting microglial functions. However sophisticated these tools have become, clear limitations remain. Understanding their pitfalls and advantages ensures their correct application. Therefore, we provide a guide to the cutting-edge methods currently available to dissect microglial biology.
Identifiants
pubmed: 34390649
pii: S0896-6273(21)00503-1
doi: 10.1016/j.neuron.2021.07.004
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
2805-2819Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.