A PBPK model describing the pharmacokinetics of γ-HBCD exposure in mice.
Brain
HBCD
PBPK
Pharmacokinetics
Toxicity
γ-HBCD
Journal
Toxicology and applied pharmacology
ISSN: 1096-0333
Titre abrégé: Toxicol Appl Pharmacol
Pays: United States
ID NLM: 0416575
Informations de publication
Date de publication:
01 10 2021
01 10 2021
Historique:
received:
23
04
2021
revised:
10
07
2021
accepted:
09
08
2021
pubmed:
15
8
2021
medline:
6
10
2021
entrez:
14
8
2021
Statut:
ppublish
Résumé
The brominated flame retardant, hexabromocyclododecane (HBCD), is added-but not bound-to consumer products and is eventually found in the environment and human tissues. Commercial-grade HBCD mixtures contain three major stereoisomers, alpha (α), beta (β), and gamma (γ), that are typically at a ratio of 12%:6%:82%, respectively. Although HBCD is widely used, the toxicological effects from its exposure in humans are not clearly understood. Using a physiologically based pharmacokinetic (PBPK) model could help improve our understanding of the toxicity of HBCD. The aim of this work was to develop a PBPK model, consisting of five permeability limited compartments (i.e., brain, liver, adipose tissue, blood, and rest of the body), to evaluate the pharmacokinetics of γ-HBCD in C57BL/6 mice. Physiological parameters related to body size, organ weights, and blood flow were taken from the literature. All partition coefficients were calculated based on the log K
Identifiants
pubmed: 34390738
pii: S0041-008X(21)00282-9
doi: 10.1016/j.taap.2021.115678
pmc: PMC8674938
mid: NIHMS1754251
pii:
doi:
Substances chimiques
Flame Retardants
0
Hydrocarbons, Brominated
0
hexabromocyclododecane
5I9835JO3M
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
115678Subventions
Organisme : Intramural NIH HHS
ID : ZIA BC011476
Pays : United States
Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.
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