In vitro models to evaluate ingestible devices: Present status and current trends.
Colon
In vitro model
Macroenvironment microenvironment
Organ-on-a-chip
Organoid
Small intestine
Stomach
Journal
Advanced drug delivery reviews
ISSN: 1872-8294
Titre abrégé: Adv Drug Deliv Rev
Pays: Netherlands
ID NLM: 8710523
Informations de publication
Date de publication:
11 2021
11 2021
Historique:
received:
10
05
2021
revised:
03
08
2021
accepted:
09
08
2021
pubmed:
15
8
2021
medline:
19
2
2022
entrez:
14
8
2021
Statut:
ppublish
Résumé
Orally ingestible medical devices offer significant opportunity in the diagnosis and treatment of gastrointestinal conditions. Their development necessitates the use of models that simulate the gastrointestinal environment on both a macro and micro scale. An evolution in scientific technology has enabled a wide range of in vitro, ex vivo and in vivo models to be developed that replicate the gastrointestinal tract. This review describes the landscape of the existing range of in vitro tools that are available to characterize ingestible devices. Models are presented with details on their benefits and limitations with regards to the evaluation of ingestible devices and examples of their use in the evaluation of such devices is presented where available. The multitude of models available provides a suite of tools that can be used in the evaluation of ingestible devices that should be selected on the functionality of the device and the mechanism of its function.
Identifiants
pubmed: 34390774
pii: S0169-409X(21)00317-3
doi: 10.1016/j.addr.2021.113924
pii:
doi:
Substances chimiques
Biocompatible Materials
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
113924Subventions
Organisme : Medical Research Council
ID : MC_PC_18040
Pays : United Kingdom
Informations de copyright
Copyright © 2021 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.