New lignans from the fruits of Leonurus japonicus and their hepatoprotective activities.
Hepatoprotective activity
Labiatae
Lignans
Mitochondrial apoptotic pathway
The fruits of Leonurus japonicus Houtt.
Journal
Bioorganic chemistry
ISSN: 1090-2120
Titre abrégé: Bioorg Chem
Pays: United States
ID NLM: 1303703
Informations de publication
Date de publication:
10 2021
10 2021
Historique:
received:
07
07
2021
revised:
02
08
2021
accepted:
03
08
2021
pubmed:
15
8
2021
medline:
31
12
2021
entrez:
14
8
2021
Statut:
ppublish
Résumé
Twelve tetrahydrofuran lignans (1-12), including six new compounds (1-6), were isolated from the 70% EtOH extract of the fruits of Leonurus japonicus. Spectroscopic analyses and ECD and OR calculations were used to determine their structures. Compounds 5 and 6 were unusual alkaloidal lignans with a butyrolactam unit. Based on the beneficial effects of the fruits of L. japonicus (Chongweizi in Chinese) on the liver in traditional Chinese medicine (TCM), the hepatocyte protective activities of the isolates were studied by MTT, Hoechst 33,342 staining, and western blotting. The MTT results revealed that compounds 1, 2, 7, and 8 significantly increased the survival rates of HL-7702 cells injured by acetaminophen, with EC
Identifiants
pubmed: 34390972
pii: S0045-2068(21)00629-5
doi: 10.1016/j.bioorg.2021.105252
pii:
doi:
Substances chimiques
Lignans
0
Protective Agents
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
105252Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.